Comparative Pharmacoeconomic Analysis of Benzathine Penicillin and Procaine Penicillin in the treatment of early syphilis in a University Teaching Hospital in Nigeria

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dc.contributor.authorGiwa, H.B.F
dc.contributor.authorGiwa, A
dc.contributor.authorOsagbemi, G.K
dc.contributor.authorAtata, R.F
dc.date.accessioned2018-06-20T11:17:55Z
dc.date.available2018-06-20T11:17:55Z
dc.date.issued2008
dc.description.abstractComparative pharmacoeconomic analysis of benzathine and procaine penicillin in the treatment of early syphilis in Ahmadu Bello University Teaching Hospital, Zaria, northern Nigeria was carried out retrospectively for prescribed/dispensed antibacterial drugs to outpatients with early syphilis among other infectious diseases, by examining outpatients case notes between 2005 and 2007. Results show that benzathine penicillin cost N 4.31/unit of effectiveness while procaine penicillin injection cost N 18.19/unit of effectiveness in the treatment of early syphilis. Benzathine penicillin injection therefore appears to be more cost effective than procaine penicllin injection. Subjecting the cost and effectiveness to sensitivity analysis did not change this conclusion. Statistical analysis shows that there is a statistically significant difference in the effectiveness (outcome) of benzathine penicillin and procaine penicillin injection, (56.2%) (χ2 = 48.58, P<0.5), Therefore there is association between effectiveness and therapeutic option chosen with benzathine penicillin being a more cost effective option. The result of this study is significant because benzathine penicillin is usually traded off for less cost-effective procaine penicillin in many cases even when there is no contraindication to the use of benzathine penicillin. Benzathine penicillin injection is more cost effective than procaine penicillin injection at their usual therapeutic dose in the treatment of early syphilis.en_US
dc.identifier.citationA. Giwa, G.K Osagbemi, R.F Atata and H.B.F Giwa (2008): Comparative Pharmacoeconomic Analysis of Benzathine Penicillin and Procaine Penicillin in the treatment of early syphilis in a University Teaching Hospital in Nigeria. Journal of Pharmacy and Bioresources, 5(2); 41-46, Published by Faculty of Pharmaceutical Sciences, University of Jos.en_US
dc.identifier.issn0189-8492
dc.identifier.urihttp://hdl.handle.net/123456789/626
dc.language.isoenen_US
dc.publisherPublished by Faculty of Pharmaceutical Sciences, University of Jos.en_US
dc.subjectPharmacoeconomics;en_US
dc.subjectSyphilisen_US
dc.subjectCost effectiveness analysis;en_US
dc.subjectBenzathine penicillin;en_US
dc.subjectProcaine penicillin,en_US
dc.titleComparative Pharmacoeconomic Analysis of Benzathine Penicillin and Procaine Penicillin in the treatment of early syphilis in a University Teaching Hospital in Nigeriaen_US
dc.typeArticleen_US

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