Assessment of Antipiperacillin IgG Binding to Structurally Related Drug Protein Adducts

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dc.contributor.authorAmali, Mohammed O
dc.contributor.authorJenkins, Rosalind E
dc.contributor.authorMeng, Xaoli
dc.contributor.authorFaulkner, Lee
dc.contributor.authorWhitaker, Paul
dc.contributor.authorPeckham, Daniel
dc.contributor.authorPark, Kevin P
dc.contributor.authorNaisbitt, Dean J
dc.date.accessioned2021-05-27T13:01:04Z
dc.date.available2021-05-27T13:01:04Z
dc.date.issued2017-11-17
dc.description.abstractThe risk of developing hypersensitivity to alternative antibiotics is a concern for penicillin hypersensitive patients and healthcare providers. Herein we use piperacillin hypersensitivity as a model to explore the reactivity of drug-specific IgG against alternative β-lactam protein adducts. Mass spectrometry was used to show the drugs (amoxicillin, flucloxacillin, benzyl penicillin, aztreonam, and piperacillin) bind to similar lysine residues on the protein carrier bovine serum albumin. However, the hapten-specific IgG antibodies found in piperacillin hypersensitive patient plasma did not bind to other β-lactam protein conjugates. These data outline the fine specificity of piperacillin-specific IgG antibodies that circulate in patients with hypersensitivity.en_US
dc.identifier.otherDOI: : 10.1021/acs.chemrestox.7b00291
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/5568
dc.language.isoenen_US
dc.publisherAmerican Chemical Society. Chemical Research in Toxicologyen_US
dc.subjectBeta lactamen_US
dc.subjectHypersensitivityen_US
dc.subjectAntibodiesen_US
dc.titleAssessment of Antipiperacillin IgG Binding to Structurally Related Drug Protein Adductsen_US
dc.typeArticleen_US

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