Kolaviron ameliorates histomorphological changes associated with Cuprizone-induced CerebellarDamage

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dc.contributor.authorOmotoso, G.O.
dc.contributor.authorOlajide, O.J.
dc.contributor.authorGbadamosi, I.T.
dc.contributor.authorSuleiman, F.A.
dc.contributor.authorOladimeji, J.O
dc.date.accessioned2025-04-29T11:12:23Z
dc.date.available2025-04-29T11:12:23Z
dc.date.issued2017
dc.description.abstractCuprizone is a copper chelator and a drug of choice in studing demyelination/remyelination in the central nervous system. This study assessed the effect of Kolaviron, on cuprizone-induced damage to the cerebellum of Wistar rat. Twenty-four adult male Wistar rats were grouped into 5: Group A received 0.5 ml of normal saline for 6 weeks; Group B received 0.5 ml of corn oil for 6 weeks; Group C was treated with 0.2% of cuprizone for 3 weeks followed by treatment with 200 mg/kg of Kolaviron for another 3 weeks; Group D received 200 mg/kg Kolaviron for 3 weeks followed by 0.2% cuprizone from another 3 weeks; while Group E received 0.2% cuprizone for 6 weeks. Meanwhile, 0.5 ml of corn oil was used as a vehicle for Kolaviron. The body and brain weight of the rats showed significant decrease in all treated groups when compared to the control groups. Histological demonstration showed varying degrees of architectural distortions, including depletion of Nissl bodies, disruption of cortical cell layers and depletion of myelin, which were more pronounced in the cerebellar cortex of cuprizone-treated rats. Kolaviron offered mild cytoprotection to the cerebellar histomorphology of cuprizone-treated rats. Further studies would ascertain the effectiveness of Kolaviron in mitigating cerebellar lesions in well-established demyelination.
dc.identifier.citationOmotoso, G.O., Olajide, O.J., Gbadamosi, I.T., Suleiman, F.A., & Oladimeji, J.O (2017): Kolaviron ameliorates histomorphological changes associated with cuprizone-induced cerebellar damage. The Journal of Anatomical Sciences, 8(2);131-137, Published by Anatomical Society of Nigeria.
dc.identifier.urihttps://www.asn-ng.com/journal/issue/8/2
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/15709
dc.language.isoen_US
dc.subjectKolaviron
dc.subjectcuprizone
dc.subjectcerebellum
dc.subjectdemyelination
dc.subjecthistomorphology
dc.titleKolaviron ameliorates histomorphological changes associated with Cuprizone-induced CerebellarDamage
dc.typeArticle

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