Kolaviron ameliorates histomorphological changes associated with Cuprizone-induced CerebellarDamage
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Date
2017
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Abstract
Cuprizone is a copper chelator and a drug of choice in studing demyelination/remyelination in the central nervous
system. This study assessed the effect of Kolaviron, on cuprizone-induced damage to the cerebellum of Wistar rat.
Twenty-four adult male Wistar rats were grouped into 5: Group A received 0.5 ml of normal saline for 6 weeks;
Group B received 0.5 ml of corn oil for 6 weeks; Group C was treated with 0.2% of cuprizone for 3 weeks followed
by treatment with 200 mg/kg of Kolaviron for another 3 weeks; Group D received 200 mg/kg Kolaviron for 3 weeks
followed by 0.2% cuprizone from another 3 weeks; while Group E received 0.2% cuprizone for 6 weeks.
Meanwhile, 0.5 ml of corn oil was used as a vehicle for Kolaviron. The body and brain weight of the rats showed
significant decrease in all treated groups when compared to the control groups. Histological demonstration showed
varying degrees of architectural distortions, including depletion of Nissl bodies, disruption of cortical cell layers
and depletion of myelin, which were more pronounced in the cerebellar cortex of cuprizone-treated rats.
Kolaviron offered mild cytoprotection to the cerebellar histomorphology of cuprizone-treated rats. Further studies
would ascertain the effectiveness of Kolaviron in mitigating cerebellar lesions in well-established demyelination.
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Keywords
Kolaviron, cuprizone, cerebellum, demyelination, histomorphology
Citation
Omotoso, G.O., Olajide, O.J., Gbadamosi, I.T., Suleiman, F.A., & Oladimeji, J.O (2017): Kolaviron ameliorates histomorphological changes associated with cuprizone-induced cerebellar damage. The Journal of Anatomical Sciences, 8(2);131-137, Published by Anatomical Society of Nigeria.