Anti-diabetic activity of aqueous extract of Senna fistula leaves in streptozotocin-induced diabetic rats
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Date
2014
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Nigerian Society of Biochemistry and Molecular Biology
Abstract
Abstract: This study aims at evaluating the antidiabetic effect of chronic administration of agueous extract of Senna fistula leaves in streptozotocin-induced diabetic rats. Thirty albino rats (110-140 g) were randomized into 6 groups (A-F) Animals in Group A was the non-diabetic control group, B was the diabetic that received distilled water, C was the diabetic animals treated with 2.5 mg/kg body weight of glibenclamide while animals in groups D, E and F were made diabetic and treated with different doses (28.57,57.14 and 114.28 mg/kg body weight) of the extract for 28 days. The results showed that the blood glucose level of diabetic rats were significantly and progressively reduced in the extract and glibenclamide treated animals when compared with the diabetic animals that received distilled water. The urine glucose and ketones which were detected in diabetic animals treated with distilled water disappeared in the extract treated animals comparable to the diabetic animals that received the reference drug.Also there was significant reduction in the postprandial blood glucose of diabetic treated animals when compared with diabetic animals that were administered distilled water throughout the exposure period. Furthermore, the level of albumin was normalized by the extract in a manner similar to those treated with glibenclamide. The significant increases in plasma cholesterol, low density lipoprotein and urea in the diabetic animals that received distilled water were reverted back to their respective control values by the extract. The high density lipoprotein was significantly different in all the treated animals. It can therefore be concluded that the oral administration of aqueous extract of Senna fistula leaves possess antihyperglycemic activity and it is also effective in controlling some metabolic disturbances associated with diabetes.
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Keywords
Senna fistula, Leguminosae, Glibenclamide, Streptozotocin
Citation
Ayinla, M.T., Owoyele, B.V. & Yakubu, M.T. (2014). Anti-diabetic activity of aqueous extract of Senna fistula leaves in streptozotocin-induced diabetic rats. Nigerian Journal of Biochemistry and Molecular Biology. 29 (2) 93-106, Published by Nigerian Society of Biochemistry and Molecular Biology. Available on line at http://www.nsbmb.org/