Evaluation of Moringa Oleifera Tree Gum as Disintegrating agent in Metronidazole Tablets
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Date
2016
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Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria
Abstract
This research was conducted to extract and purify Moringa oleifera gum (MOG) from the bark of the tree and evaluate its disintegrant property in metronidazole tablets. The gum was extracted using a standard method. Thedx gum was used as disintegrant at different concentration (0.25, 0.5, 0.75 and 1.0 %w/v) (F1 – F4) using sodium alginate gum as standard (F5 – F8) and gelatin as binder ( 1 and 2 %w/v) in metronidazole tablet. The physicomechanical properties of the dried gum particles showed excellent flow rate and Carr’s compressibility index. The physicochemical properties of the granules show free flowing compact particles. Analysis of the granule percent (%) cumulative size showed that as the concentration of MOG increases, more firm compact granules were formed. Average granule size for all the batches were retained on 500 μm. The composite granules were used to formulate metronidazole tablets using single punch tablet machine compressed at 2.0 KN. The evaluation of metronidazole tablets yielded acceptable tablets. The batches with 1% w/v gelatin as binder gave disintegration time within the acceptable limit (i.e., less than 30 minutes). The batch F4 (having 1.0 %w/v moringa gum as disintegrant) with crushing strength 55 N and friability value of 0.90 % is comparable with the batch F8 (having 1.0 % w/v sodium alginate as disintegrant) with crushing strength of 44 N and friability value of 0.77 %. The result of disintegration shows that the MOG can be effectively used as disintegrant in tablet formulation for conventional tablet at concentration of 1 % and above this concentration; it can be used as release retardant.
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Keywords
Moringa tree gum, disintegrant, wet granulation, local disintegrant