Physicochemical Properties and Compact analysis of a new Directly Compressible Filler-Binder “Tstarac” and its Utilization in the Formulation of Ascorbic Acid Tablets

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dc.contributor.authorShittu, A.O
dc.contributor.authorAfosi, A.B
dc.date.accessioned2022-02-14T09:06:35Z
dc.date.available2022-02-14T09:06:35Z
dc.date.issued2016-12
dc.descriptionPhysicochemical Properties and Compact analysis of a new Directly Compressible Filler-Binder “Tstarac” and its Utilization in the Formulation of Ascorbic Acid Tabletsen_US
dc.description.abstractAn investigation into the design of a directly compressible filler/binder from two locally available raw materials is hereby reported. ‘Nigeria tapioca starch’ (NTS) and ‘Nigeria acacia sieberiana gum’ (NASG) were both extracted using standard methods. The resultant materials were passed through mesh 60 and were then coprocessed in isopropanol and water at ratio of 2:1. NTS and NASG were arbitrarily selected at ratio 90:10, 85:15, and 80:20 which gave flow rates of 5.6, 15.1, and 20.6 g/s; angle of repose of 32.3 o , 30.0 o , and 27.5 o . Compressibility index was 20.9, 17.3 and 6.0 %; while Hausner ratio was 1.21, 1.16, and 1.06, respectively. The composite containing NTS and NASG (80:20) exhibited the best physicochemical properties and was subsequently selected for the ascorbic acid formulations. It was concluded that the coprocessed NASG and NTS have excellent compressibility and compatibility properties and can serve as cost effective excipients in conventional pharmaceutical solid dosage formulations.en_US
dc.identifier.issn2579-0455
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/7599
dc.language.isoenen_US
dc.publisherFaculty of Pharmaceutical Sciences, University of Ilorin, Ilorin, Kwara State.en_US
dc.relation.ispartofseriesVolume 1(1);1-11
dc.subjectAscorbic Acid Tabletsen_US
dc.subjectTapioca Starch-Acacia gum Tabletsen_US
dc.subjectCoprocessed fillerbinderen_US
dc.subjectTstaracen_US
dc.titlePhysicochemical Properties and Compact analysis of a new Directly Compressible Filler-Binder “Tstarac” and its Utilization in the Formulation of Ascorbic Acid Tabletsen_US
dc.typeArticleen_US

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