Cytotoxicity and Anti-Proliferative Studies of Crinum jagus L. (Amaryllidaceae) Bulb Extract

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dc.contributor.authorSalawu, M.K.
dc.contributor.authorAtunwa, S.A.
dc.contributor.authorEniayewu, O.I.
dc.date.accessioned2021-08-11T22:36:50Z
dc.date.available2021-08-11T22:36:50Z
dc.date.issued2020-07
dc.descriptionAn Experimental Study on the Anticancer Effect of Crinum jagus L. (Amaryllidaceae)en_US
dc.description.abstractCrinum jagus is a flowering plant, commonly called a poison bulb. Traditionally, the bulb extract is used in the treatment of several ailments including cancer. Cancer is a global cause of death characterized by abnormal cell proliferation. This research thus aimed to identify secondary metabolites present in the crude extract of C. jagus and evaluate its cytotoxic and antiproliferative activities using benchtop assays. The whole C. jagus bulb was collected, air-dried under the shade and extracted into distilled methanol. The extract was concentrated in vacuum and subjected to; phytochemical analysis, brine shrimp lethality (BSL) assay, Sorghum bicolor radical and Allium cepa root growth inhibitory assays. Data obtained was analyzed by Graphpad prism version 6.0. The whole bulb on extraction had a percentage yield of 12.15 % w/w. The phytochemical content of the extract includes alkaloids, flavonoids, tannins, and some glycosides. The extract demonstrated concentration-dependent brine shrimp lethality (LC50 of 65.62±0.74 μg/mL), Sorghum bicolor radical growth inhibition (IC50 = 5.36±3.21μg/mL) and significant Allium cepa root growth inhibition comparative to cyclophosphamide (a standard anticancer drug). The extract was found to be rich in secondary metabolites which elicited significant cytotoxicity and antiproliferative activities. This is the first report of antiproliferative activity of C. jagus bulb extract. Hence, this study justifies the traditional use of the bulb in the treatment of cancer. Keywords: Crinum jagus, Brine Shrimps, Sorghum bicolor, Allium cepa, Cytotoxicity, antiproliferativeen_US
dc.description.sponsorshipUniversity of Ilorin Staff Development Awarden_US
dc.identifier.citationSalawu et al., 2020en_US
dc.identifier.issn2536-6041
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/6229
dc.language.isoenen_US
dc.publisherBima Journal of Science and Technology (BJST)en_US
dc.relation.ispartofseries4(1);131-140
dc.subjectResearch Subject Categories::PHARMACY::Pharmacognosyen_US
dc.subjectResearch Subject Categories::PHARMACY::Pharmaceutical pharmacologyen_US
dc.subjectResearch Subject Categories::PHARMACY::Pharmaceutical chemistryen_US
dc.subjectResearch Subject Categories::PHARMACY::Toxicologyen_US
dc.titleCytotoxicity and Anti-Proliferative Studies of Crinum jagus L. (Amaryllidaceae) Bulb Extracten_US
dc.typeArticleen_US

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