Nutritional status of primary school children in Ilorin-West LGA, Kwara State, Nigeria.
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Date
2021-07-28
Authors
Issa, Amdallah
Abdulkadir, Mohammed B
Ibraheem, Rasheedat M
Ibrahim, Olayinka R
Bello, Surajudeen O
Suberu, Habibat D
Sanusi, Ibraheem
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Abstract
Background: A proper evaluation of cardiovascular status, with a view to
ensuring early diagnosis of cardiac dysfunction and prompt intervention
where necessary, is a recognized approach in the management of asphyxiated
neonates. Hence, we determined the levels of a cardiac biomarker (troponin I),
its relationship with disease severity, and mortality in asphyxiated neonates
with hypoxic–ischemic encephalopathy (HIE). Methods: This was a descriptive
study that involved 85 asphyxiated, term appropriate‑for‑gestational age newborn
babies with HIE (subjects) and 85 healthy controls within the first 72 h of life.
Asphyxiated neonates were classified into HIE stages using Sarnat and Sarnat
staging. Blood samples were collected between 24 and 72 h of life to determine
the level of troponin I using enzyme‑linked immunosorbent assay. The asphyxiated
babies were followed up till discharge or death. Results: The median interquartile
range level of troponin I in the subjects was higher compared with the controls,
1.26 (0.97–3.16) ng/ml versus 0.79 (0.79–1.42) ng/ml, P < 0. 001. The levels of
troponin I in HIE I, HIE II, and HIE III were 1.26 (1.00–2.37) ng/ml, 1.11 (0.86–
2.96) ng/ml, and 3.58 (1.34–5.58) ng/ml, respectively. Nonsurvivors had a higher
cardiac troponin I (4.00 [2.30–6.34] ng/ml) compared with survivors (1.21 [0.95–
2.37] ng/ml), P = 0.015. Conclusion: Cardiac troponin I was significantly higher
in asphyxiated subjects compared with healthy controls. Elevated troponin I was
associated with higher mortality. Troponin I levels in the first 72 h can help as a
prognostic indicator of HIE in term babies.
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Citation
Issa A, Abdulkadir MB, Ibraheem RM, Ibrahim OR, Bello SO, Suberu H, et al. Relationships between troponin I and hypoxic–ischemic encephalopathy among newborn babies. J Clin Neonatol 2021;10:187-91.