Cardioprotective Effects of Curcumin-Nisin Based Poly Lactic Acid Nanoparticle on Myocardial Infarction in Guinea Pigs
No Thumbnail Available
Date
2018-11-09
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Myocardial infarction (MI) is the most prevalent cause of cardiovascular death. A possible way of
preventing MI maybe by dietary supplements. The present study was thus designed to ascertain
the cardio-protective effect of a formulated curcumin and nisin based poly lactic acid nanoparticle
(CurNisNp) on isoproterenol (ISO) induced MI in guinea pigs. Animals were pretreated for 7 days as
follows; Groups A and B animals were given 0.5 mL/kg of normal saline, group C metoprolol (2 mg/kg),
groups D and E CurNisNp 10 and 21 mg/kg respectively (n = 5). MI was induced on the 7th day in groups
B-E animals. On the 9th day electrocardiogram (ECG) was recorded, blood samples and tissue biopsies
were collected for analyses. Toxicity studies on CurNisNp were carried out. MI induction caused atrial
fibrillation which was prevented by pretreatment of metoprolol or CurNisNp. MI induction was also
associated with increased expressions of cardiac troponin I (CTnI) and kidney injury molecule-1 (KIM-1)
which were significantly reduced in guinea pig’s pretreated with metoprolol or CurNisNp (P < 0.05). The
LC50 of CurNisNp was 3258.2 μg/mL. This study demonstrated that the formulated curcumin-nisin based
nanoparticle confers a significant level of cardio-protection in the guinea pig and is nontoxic.
Description
Keywords
cardiovascular death, Myocardial infarction