Antifungal activity of Dibutyl Tindisalicylates and Clotrimazole against selected Pathogenic Fungi
No Thumbnail Available
Date
2000
Journal Title
Journal ISSN
Volume Title
Publisher
The National Institute for Pharmaceutical Research and Development (NIPRD)
Abstract
In-vitro comparative study of antifungal activities of Dibutyltindisalicylates (DBTDS) and Clotrimazole (CLOT)-dermatophytic drugs of choice' against clinical isolates of Trichophyton rubrum, Trichoptiytoi violaceum. Trichophyton verricosum, Microsporum canis^ Cladosporiuni worneckii PeniciHium citrinuin,
Aspergillus nigarand Aspergillus flavus has been carried out. in-vitro estimation of minimum inhibilory
concentration (M.I.C) and minimum fungicidal concentration (M.F.C.) was by agar dilution method. The
fungistatic activities of DBTDS against, the five tested dermatophytes was 200 to 500ug /ml while that of
CLOT ranges from 400 to SOOug/ml against the same test organisms. The minimum fungicicial concentration of DBTDS and CLOT against the test fungi followed the same pattern. Comparative antifungal activity of DBTDS and CLOT against the three phytopathogenic fungi also showed that the MiC of DBTDS ranges from 200.0ug/ml to 300.0ug/ml while that of CLOT was .500.0ug/ml. using a concentration of 1.2mM, the two test compounds posses rapid fungicidal activity against the test fungi spore.s.-f or example 1.2mM of CLOT [407.0ug/ml] and DBTDS [600.00ug/ml] effected about 2.5 and 2 0 log cycle reduction of 10® cFu/ml of T. violaceum spores within five minutes contact time. Furthermore rate of kill of test fungi spores at different fungicidal concentrations of these two test compounds appear to suggest that the fungi toxic activity of DBTDS compared favourably with CLOT commonly used in the management of the superficial fungal infection in man
Description
Keywords
Antifungal, Dibutyltindisalicylate, Activity, Clotrimazole
Citation
J.O. Ehinmidu, P.F. Olurinola, A. Giwa and J.J Bonire (2000): Antifungal activity of Dibutyl Tindisalicylates and Clotrimazole against selected Pathogenic Fungi. Journal of Phytomedicine and Therapeutics, 5 (2); 88-91, Published by The National Institute for Pharmaceutical Research and Development (NIPRD)