Atypical chronic myeloid leukaemia in an adolescent nigerian: a case report and review of the literature
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Date
2017
Journal Title
Journal ISSN
Volume Title
Publisher
College of Medicine, Ambrose Alli University
Abstract
Abstract:
Atypical chronic myeloid leukaemia (aCML) is a rare subtype of CML which is now regarded as a separate clinical
entity and classified among the Myeloproliferative/myelodysplasic syndromes. It lacks the Philadelphia chromosome
and BCR-ABL fusion gene found in the classical CML. We report a case of aCML which was diagnosed and
managed at the Haematology Department of the University of Ilorin Teaching Hospital, Ilorin. Full blood count
showed anaemia, leucocytosisand presence of various forms of myeloid cells with dysplastic features. Bone marrow
aspiration done also showed myeloid hyperplasia with dysplastic changes in the myeloid cells. There was poor
outcome in the patient. This case illustrates the importance of full haematological investigations of suspected CML
cases so that the diagnosis of a CML will not be missed or passed for CML as this could influence choice of
treatment and prognosis of patients. There is need for improved diagnostic facilities in tertiary health institutions in
the country if we must achieve proper diagnosis and characterization of cases of aCML.
Description
Keywords
Atypical, CML, Adolescent, Review, Nigerian
Citation
Babatunde, A.S., Olawumi, H.O., Durotoye, I.A., Shittu, A.O., & Adepoju, A.M. (2017). Atypical chronic myeloid leukaemia in an adolescent nigerian: a case report and review of the literature. Annals of Medical Research, 6: 48 – 52. https://aauekpoma.edu.ng/index.php?option=com_content&view=categories&id=62&Itemid=232