Evaluation of the Indications and Diagnostic Value of Bone Marrow Examination in Haematological Disorders in Ilorin Nigeria: A Review of 496 Cases.
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Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
College of Health Sciences, University of Ilorin.
Abstract
Abstract
Bone marrow examination, either in the form of aspiration or biopsy, is an invasive procedure which is relatively safe and is still being performed routinely in the investigation and diagnosis of various malignant and non-malignant haematological disorders. The aims of this study were to evaluate the role of bone marrow examination in the investigation and diagnosis of haematological disorders, and the pattern of disorders diagnosed by bone marrow examination in our centre. This study was a retrospective review of all cases of bone marrow examinations which were carried out at the Haematology department of U.I.T.H Ilorin between 1st January 2005 and 31st December 2018. Case folders of all patients who had bone marrow examination done during the study period, Bone marrow aspiration and biopsy registers from Haematology department, Bone marrow reports and Full blood counts (FBC) results were retrieved and analyzed. Relevant clinical information retrieved included age, gender, clinical features at presentation, laboratory investigations, treatment regimen, and survival outcome among others. A total of 496 cases had BME performed during the study period. The patients comprised 276 (55.8%) males and 220 (44.2%) females with a M:F ratio of 1.3:1. Their median age was 38.5 years (age range 16 months and 85 years). Pathological marrow with diagnosis on BME was found in 441 (88.9%) while normal marrow (negative for any pathologic condition) was seen in 55 (11.1%) of patients. The leukemias (acute and chronic) were the commonest haematological disorders found on bone marrow examination, constituting 37.8% of cases. Unexplained anaemia was the commonest clinical feature at presentation necessitating bone marrow examination. Bone marrow examination is still very useful as a diagnostic tool in the hand of Haematologists in the investigation and diagnosis of various haematological disorders, and is relatively safe to perform even with presence of thrombocytopenia.
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Keywords
Indications,, Diagnostic value,, Haematological,, Bone marrow examination,, Ilorin
Citation
2. Babatunde, A.S., Durotoye, I.A., Shittu, A.O., Omokanye, K.O., Ogunfemi, M.K., & Owoeye O.A. (2020). Evaluation of the Indications and Diagnostic Value of Bone Marrow Examination in Haematological Disorders in Ilorin Nigeria: A Review of 496 Cases. Tropical Journal of Health Sciences, 27(1): 27 -33.