Respiratory papillomatosis in Northern Nigeria: A 7-year Review.

Afolabi, O.A ; Bature, I. F, ; Mainasara, M G, ; Labaran, A. S, ; Musa, K. A, ; Ghazali, B T, ; Ahmad, B. M. (2016)

Respiratory papillomatosis in Northern Nigeria


Background: Recurrent respiratory papillomatosis (RRP) is a benign disease of the upper respiratory tract caused by human papilloma virus (HPV), which can occur at any part of the upper aerodigestive tract. The aim of this study was to determine the prevalence and clinical outcome of RRP in northern Nigeria. Materials and Methods: This study was a retrospective review of patients with the diagnosis of RRP who presented to the National Ear Care Center over a 7-year period (2005-2011). All the case notes of these patients were retrieved, and information gathered from the clinical records were entered into SPSS statistical software and analyzed descriptively. The results were presented in tables and figures. Results: A retrospective review of 24 patients in the age range of 3-51 years with a mean age of 13.4 years was done. There were 14 males and 10 females. The firstborn male children were more affected than the females. The duration of symptoms before presentation varied within the range of 1-276 months, with an average of 48.3 months. Laryngoscopic examination revealed 15 supraglottic, 3 transglottic, and 6 glottic masses. A clinical diagnosis of juvenile-onset recurrent respiratory papillomatosis (JORRP) was made in 20 patients, while adult-onset (AORRP) diagnosis was made in 4 patients. The majority of the patients had direct laryngoscopy and clearance biopsy with tracheostomy (in over 50%). The treatment outcome showed that 18 patients had improved satisfactory postoperative voice, 5 had not improved to their satisfaction, and 1 patient was equivocal. Conclusion: RRP is still a challenge because it has delayed presentation. Juvenile onset is the most commonest. It occurs more among males, first born and treatment still remains DL + biopsy clearance + tracheostomy in our setting.