Drug of Choice in the Treatment of Multiple Drug Resistant (MDR) Salmonellae Isolated from Wildlife in Nigeria
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Date
2019-12
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Journal ISSN
Volume Title
Publisher
Faculty of Veterinary Medicine, University of Abuja
Abstract
Multiple drug resistant (MDR) strains of Salmonella are frequently encountered with increased
rates in recent years. Many variants of the organism have developed MDR genes which they retain
even when antimicrobial drugs are no more in use, limiting the choice of drugs for therapy of
Salmonella infections resulting in morbidity and mortality in both man and animals and raising
more public health questions. The objective of this study was to evaluate the susceptibility of
Salmonella spp. to twelve antimicrobial agents using the disk diffusion method. Eight Salmonella
spp. isolated from wildlife were tested. All the isolates exhibited MDR, showing resistance to at
least four and up to nine antimicrobial agents. They were all highly resistant (100%) to
ceftazidime, cephazoline, cefuroxidine and ampicillin but were susceptible to nalidixic acid and
ciprofloxacin. Six resistant patterns were observed, with ampicillin-cefuroxime sodiumcephazolin-
ceftazidime and streptomycin-ampicillin-cefuroxime sodium-cephazolin-ceftazidime
resistant patterns exhibited by two isolates each. The substantial multiple resistance pointed to the
fact that limitations could be faced in choosing drugs for the treatment of Salmonella infections and
that mortality and economic losses could be experienced especially if sensitivity tests are not
carried out before antimicrobial choice is made for treatments in both man and animals.
Description
Keywords
multiple drug resistance, Salmonella, mortality, wildlife, man
Citation
Oludairo et al., 2019