The GC-MS fingerprints of Nicotiana tabacum extract and propensity for renal impairment and modulation of serum triglycerides in Wistar rats
No Thumbnail Available
Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Pharmacy & Pharmacognosy Research
Abstract
Context: Nicotiana tabacum is an herbaceous plant mostly known as tobacco. Locally, people do extract this plant with cow urine, they call it “Adimenu” and they claimed it is effective in managing various ailments, even with taking just a spoonful of the extract. Thus, profiling the toxicity and or otherwise of the cow-urine extracted tobacco plant cannot be overemphasized.
Aims: To characterize the cow urine extracts of N. tabacum and evaluated the sub-acute toxicity of smokeless exposure in male Wistar rats.
Methods: Forty Male Wistar rats were randomly assigned into groups and exposed to different doses (50, 100 and 200 mg/kg body weight) of N. tabacum extract for 7 and 28 days, after which the animals were sacrificed for the biochemical assays.
Results: The GC-MS analysis revealed 21 compounds in the N. tabacum extract. As expected, nicotine was predominant among the identified compounds. The sub-acute exposure of rats to cow-urine extract of N. tabacum extract might have altered rat metabolic homeostasis, triggering adaptive mechanisms, while impairing renal functions. The N. tabacum extract also modulated (p<0.05) rat serum lipid profile when compared with control.
Conclusions: Findings in this study suggest that the cow-urine extract of N. tabacum exposure in male Wistar rats might have perturbed renal functions while predisposing to cardiac agitation. This research therefore recommends to local consumers to be cautious of the rate at which they consume their regular “Adimenu”.
Description
This study revealed the biochemical effects of N. tabacum extract in Wistar rats following a sub-acute oral exposure. Our findings support adap-tive mechanisms in rats as a result of oral exposure to N. tabacum extract. Conversely, the extract ad-ministration to rats might have led to the ensuing renal impairment. Additionally, the sub-acute ad-ministration of N. tabacum extract raised the rat serum triglycerides in a manner that may predis-pose to cardiac agitation. This research therefore recommends to local consumers of the concoction to be cautious of the rate at which they consume their regular “Adimenu”, the cow-urine extracted N. tabacum.
Keywords
biochemical toxicity, safety assessment, lipid profiling, medicinal biochemistry
Citation
Faoziyat A. Sulaiman, Mikail O. Nafiu, Babalola O. Yusuf, Hamdalat F. Muritala, Sherif B. Adeyemi, Sikemi A. Omar, Kehinde A. Dosumu, Zainab J. Adeoti, Oluwafunmilayo A. Adegbesan, Basirat O. Busari, Fadipe John, David A. Otohinoyi, Damilare Rotimi, Gaber E. Batiha, Oluyomi S. Adeyemi1 (2020). The GC-MS fingerprints of Nicotiana tabacum extract and propensity for renal impairment and modulation of serum triglycerides in Wistar rats. Journal of Pharmacy & Pharmacognosy Research ISSN 0719-4250. http://jppres.com/jppres J Pharm Pharmacogn Res 8(3): 191-200, 2020. Available online at http://jppres.com/jppres/pdf/vol8/jppres19.594_8.3.191.pdf and http://jppres.com/jppres/nicotiana-tabacum-causes-renal-damage/