Lipid profile in subfertile clients with premature ovarian failure: University of Ilorin Teaching Hospital
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Date
2018
Journal Title
Journal ISSN
Volume Title
Publisher
Krishna Institute of Medical Sciences
Abstract
Background: Premature Ovarian Failure (POF) is
associated with a higher incidence of cardiovascular
events later in life. Concurrent with the ages of
menopausal transition, a shift in lipid profile takes
place. The increased burden may be mediated by a
worsening of cardiovascular risk factors, such as lipids,
corresponding with the loss of ovarian function. Aim
and Objectives: To investigate serum lipid and
hormonal levels in women with premature ovarian
failure and compare with those of apparently healthy
women of similar age. Material and Methods: The
study was a cross-sectional one in which serum fasting
Total Cholesterol (TC), Triglycerides (TG), High
Density Lipoprotein Cholesterol (HDL-C) and Low
Density Lipoprotein Cholesterol (LDL-C) levels were
measured in 50 women with POF and compared with 40
age matched control. Serum hormonal profiles were
compared with lipid profiles and biomarkers of
atherogenic index were assessed. Results:Women with
POF present with statistically significant elevations in
the mean values of serum FSH and LH, when compared
with those of controls (p<0.001), while there were
significant decrease in mean levels of serum prolactin,
progesterone, testosterone and oestradiol when subjects
were compared with controls (p<0.001). There were
statistically significant elevations in serum total
cholesterol, triglycerides, HDL-C and LDL-C, in
premature ovarian failure subjects when compared with
controls (p<0.001). There was statistically significantly
difference when mean values of artherogenic index and
Castelli ratio II of subjects were compared with those of
controls. Conclusion: Loss of ovarian function at a very
young age (POF) was characterized with subtle changesin the serum lipid profile (higher TC, TG, HDL-C, and
LDL-C levels). It also shows that atherogenic index and
Castelli ratio II are better tools for assessment of
atherogenicity than CHD risk ratio and Castelli ratio I in
patients with POF.
Description
Keywords
Lipid profile, atherogenicity, premature ovarian failure