Preparation, Characterization and Biological Studies of Metal Complexes of Mixed Ligands of Nicotinamide and Metronidazole
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Date
2017-10-25
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Nigerian Society of Biochemistry and Molecular Biology
Abstract
The Mn2+, Fe2+, Cu2+, Co2+, Zn2+ and Ni2+ complexes of mixed nicotinamide and metronidazole were prepared and characterized using solubility, melting point, conductivity measurement, CHNO (carbon, hydrogen, nitrogen, oxygen) elemental analysis, powder X-ray diffraction and infrared spectroscopy . The results of the physical and spectroscopic data confirm the formation of the complexes. For nicotinamide, coordination of the metal to the ligands occurred through the nitrogen of the pyrimidine group, while for mertonidazole, coordination took place through the nitrogen of the amine group. The antibacterial activity of the complexes was carried out against Staphylococcus aureus, Pseudomonas aureginosa, Klebsiella spp, Escherichia coli and Candida spp. Only Cu(II) mixed complex had high inhibitory activity against all three bacteria species. The results of antifungal activity show that all the complexes have no inhibitory activity against the two fungi species compared with the corresponding ligands
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Keywords
Nicotinamide, Metronidazole, complexes, Transition metal, Spectroscopy, Antimicrobial