ACUTE AND SUBACUTE TOXICITY STUDIES ON METHANOL LEAF EXTRACT OF TURRAEA VOGELII HOOK. F. EX. BENTH.
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Date
2018
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Faculty of Pharmaceutical Sciences Ahmadu Bello University Zaria
Abstract
In Africa, majority of people rely on medicinal plants for their health care needs as well as for food. There are numerous scientific reports on efficacy of medicinal plants, with limited reports on the safety of these plants. Turraea vogelii Hook. f. ex. Benth. is an ethno medicinal plant indigenous to Tropical Africa. It is used as food, drinks and widely explored in ethno medicine for treatment of various ailments including; wounds, stomach
ache, malaria fever, intestinal worms and urogenital infections. The aim of this study was to evaluate the acute and subacute oral toxicity of methanol leaf extract of T. vogelii in experimental animals. Acute oral toxicity was determined following OECD guideline 423. Doses of 125, 250, 500 mg/kg were administered for 28 days in the subacute oral toxicity study. Effect of extract on haematological parameters, liver and kidney function
markers were determined. The acute oral toxicity of Turraea vogelii was estimated to be greater than 2000mg/kg. The extract had no significant effect on haematological parameters, liver and renal function parameters when compared with the control. The extract however produced inflammatory changes and alterations in morphology of the liver. The results from this study shows that the methanol leaf extract of Turraea vogelii
produced toxic effects on the liver when repeated oral doses were administered.
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Keywords
Turraea vogelii, Subacute, Toxicity, Haematology, Kidney, Liver