Normal CD4+ Cell Count Range Amongst Healthy Nigerian Population In Ilorin,

Afolabi, J. K. ; Fadeyi, A ; Desalu, O. O. ; Durotoye, I. A. ; Fawibe, A. E. ; Adeboye, M. A. N. ; Olawumi, H. O. ; Babatunde, A. S. ; Ernest, S. K. ; Aderibigbe, S. A. ; Saadu, R. ; Salami, A. K. ; Aboyeji, A. P. (2014)


Background: For the establishment and monitoring of the immune status, CD4 count is critical. Objectives: To determine the CD4 count range of apparently healthy Nigerians resident in Ilorin and compare with the national value. Methods: An automated blood analyzer was used to determine the full blood count and CD4 count. The percentage of CD4 count was derived by using other variables. Results: Of the 1205 participants, the reference CD4 count (percentage of CD4) range for adult was 400 to 1288 cells/mm 3 (19%-48%) and for children was 582 to 3652 cells/mm 3 (17%-50%). CD4 count and percentage of CD4 were significantly (P 1⁄4 .001) higher in females than in males, and the CD4 count declined significantly with increasing age (r 1⁄4 .174, P .0001). The percentage of CD4 count shows less variation with age (r 1⁄4 .051, P 1⁄4 .076). Adult residents of Ilorin had significantly lower absolute mean CD4 count (808 + 260) than that of the national reference values of 847.0 + 307.0 cells/mm 3 (P 1⁄4 .001). Conclusion: We therefore advocate the use of CD4 count range derived in this study is lower than that of the national reference values.