Nigerian Journal of Biochemistry and Molecular Biology
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Date
2014-10-01
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Publisher
Nigerian Society of Biochemistry and Molecular Biology
Abstract
Physalis angulata is a specie of the Solanaceae family, in which edible fruit is used in several countries of tropical and subtropical regions of the world as medicinal and fruit-tree. In this study, the secondary metabolite screening of the crude extracts consisting of (ethanol, ethylacetate, chloroform and n-hexane) of the whole plant and antibacterial activity was investigated against some clinical isolates. The screening of the secondary metabolites revealed some active components such as alkaloids, tannins, terpenoids, phenolics and flavonoids. The antimicrobial screening of the ethanolic extract of the plant at concentrations of 25, 50, 100 and 125 mg/ml revealed various zones of inhibition from 8.2 to 17.2 mm for the different organisms. In conclusion, the extract of Physalis angulata exhibited antibacterial activity made possible by the presence of the secondary metabolite constituents and therefore could be used as antibiotic against the bacteria strains investigated in this study.
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Keywords
Physalis angulata, Solanaceae, Antibacterial, Clinical isolates