Altered testicular histomorphometric and antioxidant levels following in vivo bisphenol-a administration
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Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
Arak University of Medical Sciences
Abstract
Background: Bisphenol-A (BPA) is a pervasive environmental toxin that is used in the
production processes of many consumables and equipment that are in daily application. The
aim of this study was to determine the effects of BPA on the structural and functional integrity
of the reproductive system in male Wistar rats and its interaction with melatonin.
Methods: Adult female rats in pro-estrus phases were mated with adult male rats and the
conception determined. The male pups were divided into two groups of A and B. These
groups were further subdivided into six subgroups each. They were administered varying low
doses of BPA (25 or 50mg/kg) and melatonin (10mg/kg) at neonatal and adolescent ages. The
testes, epididymis and blood samples were collected for histological, semen and biochemical
investigations, respectively.
Results: The results show that BPA caused histological alterations, reduced quality and
quantity of sperm cells, and induced oxidative stress at birth and adolescence.
Conclusion:Bisphenol A exposure, even at low dose, is toxic to the male reproductive system,
and melatonin administration did not significantly improve the alterations caused by the BPA.
Description
Keywords
Adolescence, Bisphenol A, Histology, Melatonin, Neonate
Citation
Kadir, R. E., Ojulari, S. L., Gegele, A. T., Lawal, A. I., Sulu-Gambari, L., Sulaimon, F. A., & Omotoso, G. O. (2021). Altered testicular histomorphometric and antioxidant levels following in vivo bisphenol-a administration. Iranian Journal of Toxicology. 15 (3), 165-174