Browsing by Author "Yahaya, T"
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Item Characterization, Anti-inflammatory and Anti-microbial Potentials of a Herbal Preparation(Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria, 2019-03) Njinga, Stanislaus; Bakare-Odunola, Mojisola; Mustapha, K.B.; Yahaya, T; Shittu, Abiodun; Bello, H.R; Abdullahi, Sa'ad; Usman, Sukurat; Ayanniyi, Rashidat; Olufadi-Ahmed, HayishaHerbal product (HP) (from Ricinus communis and honey) is used locally for the management of inflammatory and inflammation related disorders including asthma. The current study was carried out to determine the phytochemicals, total phenolic and flavonoid contents, chemical profile, elemental components, anti-inflammatory and antimicrobial activity of the HP used for treatment of asthma. Total phenolic and flavonoid contents were determined by the Folin-Ciocalteus reagent and AlCl3 colorimetric method respectively. The chemo-profiling was done using TLC. Elemental analysis was determined using Atomic Absorption Spectroscopy (AAS). Albumin-induced paw oedema model was used to determine the anti-inflammatory activity while agar well diffusion method was used to determine the antimicrobial activity of the HP at different concentrations. Flavonoids, saponins, alkaloid, cardiac glycoside, steroids and terpenoids were detected in the HP. Total phenolic and flavonoid contents obtained were 10.00 mg/g gallic acid equivalent and 336.60 mg/g quercetin equivalent respectively. The chemo-profiling showed one spot at 254 nm but none at 366 nm. AAS indicated the presence of K, Ca, Fe, Na, Zn, Cu and Pb (Cu and Pb were within WHO acceptable limit). The 100 % concentration produced sudden but transient significant reduction in oedema size at 30 minutes. However, at 60 minutes the effect produced at 25 % was comparable to that of Ibuprofen at 20 mg/kg body weight. At 100% concentration HP all the organisms tested were sensitive except for Pseudomonas aeruginosa. The presence of flavonoids may justify the anti-inflammatory and antimicrobial activities thus validating its use in local treatment of Asthma.Item CHARACTERIZATION, ANTI-INFLAMMATORY AND ANTIMICROBIAL POTENTIALS OF A HERBAL PREPARATION(Nigerian Journal of Pharmaceutical Sciences, 2019-03) Njinga, Stanislus Ngaitad; Bakare-Odunola, M.T; Mustapha, K.B; Yahaya, T; Shittu, Abiodun; Bello, Ronke Hadiyyah; Abdullahi, S.T.; Usman, S.O.; Ayanniyi, Rashidat Oluwafunke; Olufadi-Ahmed, HaishatHerbal product (HP) (from Ricinus communis and honey) is used locally for the management of inflammatory and inflammation related disorders including asthma. The current study was carried out to determine the phytochemicals, total phenolic and flavonoid contents, chemical profile, elemental components, anti-inflammatory and antimicrobial activity of the HP used for treatment of asthma. Total phenolic and flavonoid contents were determined by the Folin-Ciocalteus reagent and AlCl3 colorimetric method respectively. The chemo-profiling was done using TLC. Elemental analysis was determined using Atomic Absorption Spectroscopy (AAS). Albumin-induced paw oedema model was used to determine the anti-inflammatory activity while agar well diffusion method was used to determine the antimicrobial activity of the HP at different concentrations. Flavonoids, saponins, alkaloid, cardiac glycoside, steroids and terpenoids were detected in the HP. Total phenolic and flavonoid contents obtained were 10.00 mg/g gallic acid equivalent and 336.60 mg/g quercetin equivalent respectively. The chemo-profiling showed one spot at 254 nm but none at 366 nm. AAS indicated the presence of K, Ca, Fe, Na, Zn, Cu and Pb (Cu and Pb were within WHO acceptable limit). The 100 % concentration produced sudden but transient significant reduction in oedema size at 30 minutes. However, at 60 minutes the effect produced at 25 % was comparable to that of Ibuprofen at 20 mg/kg body weight. At 100% concentration HP all the organisms tested were sensitive except for Pseudomonas aeruginosa. The presence of flavonoids may justify the anti-inflammatory and antimicrobial activities thus validating its use in local treatment of AsthmaItem CHARACTERIZATION, ANTI-INFLAMMATORY AND ANTIMICROBIAL POTENTIALS OF A HERBAL PREPARATION(Faculty of Pharmaceutical Sciences Ahmadu Bello University Zaria, 2019) Njinga, N.S; Bakare-Odunola, M.T; Mustapha, K.B; Yahaya, T; Shittu, A.O; Bello, H.R; Usman, S.O; Ayanniyi, R.O; Olufadi, H.YHerbal product (HP) (from Ricinus communis and honey) is used locally for the management of inflammatory and inflammation related disorders including asthma. The current study was carried out to determine the phytochemicals, total phenolic and flavonoid contents, chemical profile, elemental components, anti-inflammatory and antimicrobial activity of the HP used for treatment of asthma. Total phenolic and flavonoid contents were determined by the Folin-Ciocalteus reagent and AlCl3 colorimetric method respectively. The chemo-profiling was done using TLC. Elemental analysis was determined using Atomic Absorption Spectroscopy (AAS). Albumin-induced paw oedema model was used to determine the anti-inflammatory activity while agar well diffusion method was used to determine the antimicrobial activity of the HP at different concentrations. Flavonoids, saponins, alkaloid, cardiac glycoside, steroids and terpenoids were detected in the HP. Total phenolic and flavonoid contents obtained were 10.00 mg/g gallic acid equivalent and 336.60 mg/g quercetin equivalent respectively. The chemo-profiling showed one spot at 254 nm but none at 366 nm. AAS indicated the presence of K, Ca, Fe, Na, Zn, Cu and Pb (Cu and Pb were within WHO acceptable limit). The 100 % concentration produced sudden but transient significant reduction in oedema size at 30 minutes. However, at 60 minutes the effect produced at 25 % was comparable to that of Ibuprofen at 20 mg/kg body weight. At 100% concentration HP all the organisms tested were sensitive except for Pseudomonas aeruginosa. The presence of flavonoids may justify the anti-inflammatory and antimicrobial activities thus validating its use in local treatment of Asthma.Item Hardness and Tensile Properties of Prophylactic Knee Brace Produced from Cow Bone and Periwinkle Shell Composites(Dhaka University of Engineering & Technology, Gazipur, Bangladesh, 2019-06) Abdulkareem, S.; Adekaye, T. A.; Abdulrahim, A. T.; Shuaib-Babata, Y. L.; Ajiboye, T. K.; Ahmed, I. I.; Ibrahim, H. K.; Adebisi, J. A.; Yahaya, TApplication of reinforced aluminium scrap for the production of prophylactic knee brace (Pkb) particularly with agro-waste materials is rarely available. In this work, hardness and tensile properties of aluminium alloy (Al 6063) straps reinforced with cow bone (Cb) and periwinkle shell (Ps) for the production of Pkb were investigated. The Cb and Ps sourced were cleaned and the Cb was sun-dried for 4 weeks before crushing with Denver laboratory Ball mill (Model: 48-D0500/Q). The Ps was also crushed, sun-dried for 7 days and treated in the oven (Model SDO/225) at 110 oC for 30 minutes to remove moisture. The particle size of 75 μm was used to cast six (6) each of aluminium/cowbone (Al/Cb) and aluminium/periwinkle shell (Al/Ps) composites. The cast aluminium composites of Pkb and original Pkb were investigated for density, hardness, and tensile properties. It was observed that addition of Cb and Ps in the cast Pkb gave a density of 2.68 g/cm3 and 2.60 g/cm3 respectively. The average values of hardness and tensile strength obtained were 41.18 BHN and 135.88 MPa respectively when Ps was added to the cast aluminium Pkb, while addition of Cb gave harness values of 40.45 BHN and tensile strength of 134.63 MPa.Item Potential of cow horn for carbonitriding treatment of steel(Springer Link (Waste Biomass Valor), 2018-02-07) AMBALI, IBRAHIM OWOLABI; Ahmed, I.I; Mohammed, A.T; Abdulkareem, S; Yahaya, T; Bayode, B. LThe potential of carbonitriding treatment of steel with cow horn was investigated in line with abattoir waste to wealth approach of waste management. The objectives of the study included processing of cow horn into different morphologies namely: powder and flakes for carbonitriding heat treatment, and, chemical analyses of cow horn with Energy Dispersive Spectroscopy (EDS) and X-ray Diffraction (XRD) techniques to determine the chemical composition and phases of cow horn respectively. The heat treatment was carried out at 850 and 450 °C for carburizing and nitriding dominated processes respectively. Vickers hardness measurement was carried out to determine the hardness profile on carbonitrided samples. Optical metallography was carried out for microstructural examination and to investigate phase contrast between the case and core of carbonitrided sample. The result of hardness test observed is consistent with the case hardening profile with higher hardness value at near surface decreasing towards core. Sample heat treated with horn flakes showed higher hardness than those with horn powder. Microstructural phase contrast showed delineation of the hardened case and soft inner core. The high hardness of case was attributed to diffusion of carbon and nitrogen atoms from the cow horn to iron interstices. This supposition was corroborated by detection of carbon and nitrogen with EDS and XRD tests. It was therefore concluded that cow horn could be processed as candidate materials for carbonitriding of steel.