Browsing by Author "Suleiman, Faoziyat A."

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    Assessment of the effects of ethanolic extracts of Annona squamosa leaves and stem on selected biochemical parameters
    (Nigerian Society for Experimental Biology, 2020) Suleiman, Faoziyat A.; AbdulRaheem, A. M. O.; Garuba, Taofeeq; Abubakar, F. A.; Giwa, E.
    Plants are rich sources of secondary metabolites with interesting biological and medicinal activities. Compounds from plants continue to play a major role in primary health care as therapeutic remedies in many developing countries. Natural remedies from medicinal plants are found to be safe and effective. Many plant species have been used to treat various ailments including Annona squamosa, its various plant parts, stem, leaves, roots, etc has been used locally to manage various ailments, hence the need to assess its safety and possible effects on some endogenous biochemical markers. A completely randomized design (CRD) was used in this experiment. The ethanolic extracts of leaves and stem of Annona squamosa were used in this research to investigate the effect on some selected biochemical parameters in healthy Wistar rats. Twenty experimental animals were randomly distributed into four (4) groups of five (5) animals each. Group A (Control) was administered appropriate volume (1ml) of distilled water, Group B was administered 50mg/kg bodyweight of Cyclophosphamide, Group C was administered 500mg/kg bodyweight of ethanolic extract of Annona squamosa leaf, Group D was administered 500mg/kg bodyweight of ethanolic extract of Annona squamosa stem. All of the doses were administered orally daily for 21 days. There was an increase in serum Alanine amino transaminase (ALT), Aspartate Amino Transaminase (AST) and Alkaline Phophatase (ALP) activity in the serum of the cyclophosphamide treated group and a subsequent decrease of these enzymes in the liver, kidney and heart. The groups administered with ethanolic extracts of Annona squamosa leaves and stem compared favourably with the control group in ALT, AST, and ALP activity in the serum, kidney, liver, and heart. The study showed that there was a significant rise in High-density Lipoprotein(HDL) concentration and albumin concentration and a decrease in Triglyceride concentration, bilirubin concentration, urea, and creatinine concentration in the groups administered 500mg/kg bodyweight of Annona squamosa leaves and stem.
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    Lipid and Antioxidant Profile of Chitosan Bound Ethylacetate Fractionsof Cocos nucifera Husk Fiber in Plasmodium berghei InfectedMice
    (Society for Experimental Biology of Nigeria, 2019) Suleiman, Faoziyat A.; Oloyede, H. O. B.; Akanji, Musbau A.; Abdulraheem, A. M. O.; Akolade, Jubril O; Garuba, Taofeeq; Onaeko, Elizabeth T.; Aliyu, Najeeb O.; Balogun, Basheer A.
    Malaria is a parasitic disease that occurs in tropical and subtropical regions of the world. About 500 millioncases of malaria occur every year, and one million people, mostly children living in sub-Saharan Africa, dieas a result. This study was conducted to determine the lipid and antioxidant status of chitosan boundethylacetate fraction of cocos nucifera husk fiber in p. berghei infected mice. Swiss albino mice wereinnoculated with Plasmodium berghei. The forty five mice were randomly assigned into nine groups, of 5mice each. Administration of the Therapeutic Dose (TD) (80mg/kg) and Sub Therapeutic Dose (STD) (20mg/kg) (gotten from preliminary studies) of ethylacetate extract fraction of Cocos nucifera husk fibre coupled with chitosan and chitosan/alginate was done orally for four days post-inoculation and 0.2ml of theextract was administered. Group A served as positive control (not infected), Group B received appropriatevolume of distilled water, Group C received 5mg/kg. Chloroquine (infected), Group D received80mg/kg of extract (therapeutic dose), Group E received20mg/kg of extract ( sub-therapeutic dose, infected), GroupFreceived80mg/kg of extract + Chitosan + infected, Group G received20mg/kg of extract +Chitosan+infected, Group H received80mg/kg of extract + Chitosan/ Alginate + infected, Group I received20mg/kg of extract + Chitosan/Alginate + infected. At the end of the experimental period, selected tissues was collected, isolated and homogenized. Antioxidant (MDA, GSH and GST) and lipid profile activities (Cholesterol, HDLand LDL) were determined. The results reveal that, there was a significantly decreased in the level of thenon-treated groups as compared to other treated groups and control in cholesterol, HDL and LDLlevel while there was significant increase in triacylglyeride level in non – treated groups compared to other test groups and control after the administered ethylacetate fraction of cocos nucifera bound to chitosanmicroparticles. In present study reduced glutathione (GSH), GST and lipid peroxidation product malondialdehyde (MDA) were increased significantly compared to test groups and control. These resultssuggest that ethylacetate fraction of Cocos nucifera husk fibre bound to chitosan microparticles may boost body’s antioxidant systems, which neutralizes the ef ects of free radicals and also able to reverse the changein serum lipid profile caused by malaria infection.