Browsing by Author "Sulaimon F.A."

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    Altered testicular histomorphometric and antioxidant levels following in vivo Bisphenol-A administration
    (School of Medicine, Arak University of Medical Sciences, 2021) Kadir R.E.; Ojulari L.S.; Gegele T.A.; Lawal I.A.; Sulu-Gambari L.; Sulaimon F.A.; Omotoso G.O.
    Background: Bisphenol-A (BPA) is a pervasive environmental toxin that is used in the production processes of many consumables and equipment that are in daily application. The aim of this study was to determine the effects of BPA on the structural and functional integrity of the reproductive system in male Wistar rats and its interaction with melatonin. Methods: Adult female rats in pro-estrus phases were mated with adult male rats and the conception determined. The male pups were divided into two groups of A and B. These groups were further subdivided into six subgroups each. They were administered varying low doses of BPA (25 or 50mg/kg) and melatonin (10mg/kg) at neonatal and adolescent ages. The testes, epididymis and blood samples were collected for histological, semen and biochemical investigations, respectively. Results: The results show that BPA caused histological alterations, reduced quality and quantity of sperm cells, and induced oxidative stress at birth and adolescence. Conclusion: Bisphenol A exposure, even at low dose, is toxic to the male reproductive system, and melatonin administration did not significantly improve the alterations caused by the BPA
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    Cage Migration and Memory: Investigating the Impact of Varied Cage Sizes on Memory Function in Swiss Mice
    (Society of Experimental and Clinical Anatomists of Nigeria, 2024) Oyewole, A.L.; Ishola S.S.; Oyafemi K.O.; Badmus K.S.; Omoleye J.O.; Abubakar M.F.; Adeniyi-Raheem O.; Amedu A.; Lawal D.L.; Ijiyode A.O.; Yussuf A.O.; Yakub Y.O.; Ogunjimi G.L.; Sulaimon F.A.
    BACKGROUND AND AIM: Diverse cage sizes have been implicated in the alteration of pain sensitivity and inflammation parameters in animal-based experiments. Sparse information is available on the effect of exposure to different cage sizes on memory in animal studies. This study thus aimed to investigate the effect of varied cage size exposure on memory. METHODOLOGY: Twelve adult male Swiss mice (29-34 g) divided into two groups (n=6) were used for this study, comprising a Control group (stationary cage) and a Test group (migrated cage). The cage migrated mice were exposed daily to various cage sizes typically used in Nigerian laboratories for 30 days. In contrast, the cage-stationed mice were daily exposed to new but the same size and shape cage. After 30 days of exposure, memory functions were assessed in the animals using memory-related behavioural paradigms (such as novel object recognition test), acetylcholinesterase activity and histological evaluation. RESULTS: The results showed no significant difference in the recognition and spatial memory of cage migrated animals compared to its cage stationed counterparts. The brain acetylcholinesterase activity significantly (p < 0.05) decreased in cage-migrated mice compared to cage-stationed animals but there was no difference in plasma acetylcholinesterase activity in both groups. Also, histological evaluation of all regions of the hippocampus in both groups of animals did not show any significant difference. Though cornu ammonis regions appeared to be enlarged in cage migrated animals compared to cage stationed. CONCLUSION: Repeated exposure of experimental mice to varied cage sizes could selectively decrease brain acetylcholinesterase activity without affecting the animals’ memory
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    Comparative Study of the Thyroid Gland of Juvenile Male Guinea Pigs and Grass-cutters: Hematological and Hormonal Profile
    (Anatomical Society of Nigeria, 2025) Sulaimon F.A.; Ibiyeye R.Y.; Imam A.L.; Shehu M.; Abioye, A.I.‘R.; Ajao M.S.
    This study presents a comparative examination of the hematological parameters, structure, and function of the thyroid gland between two rodent species: guinea pigs (Cavia porcellus) and grasscutters (Thryonomys swinderianus), which are taxonomically distinct. They are important for research and agriculture, yet little is known about their comparative thyroidal morphology, physiology, and hematological profiles. The study utilized six grasscutters and six guinea pigs with an average weight of 1800±530 g and 210±20 g, respectively. The thyroid gland of the guinea pigs is compact, while the grasscutters are bilobed without an isthmus joining the lobes. The average weight of the guinea pigs’ and the grasscutters’ thyroid gland weight was found to be 1.69±0.26 g and 2.81±0.37 g, respectively. The relationship between thyroid hormones (triiodothyronine [T3] and thyroxine [T4]) of the guinea pigs and grasscutters was found to be in line with that of most mammals, with the T4 concentration being significantly higher than the T3 concentration. The differences in the Red Blood cell properties of the guinea pigs and grasscutters were found to be significant at P<0.05, being significantly higher in grasscutters. The differences in the guinea pigs’ and grasscutters’ white blood cell indices were not statistically significant at P<0.05. This study contributes to a deeper understanding of the comparative endocrinology and hematology of guinea pigs and grasscutters, with implications for their use in physiological, toxicological, and pharmacological studies
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    Moringa oleifera attenuates biochemical and histological changes associated with the pancreas in nicotine-treated rats
    (Research Journal of Health Sciences, 2018) Omotoso G.O.; Adunmo G.O.; Ojulari L.S.; Olawuyi T.S.; Lewu F.S. ,; Jaji-Sulaimon R.; Sulaimon F.A.; Gbadamosi I.T. ,; Onoja O.P.
    Objective: The study was undertaken in order to evaluate the beneficial potential of Moringa oleifera, in nicotine-induced pancreatic injury. Method: Forty-five adult female albino rats were divided into 5 groups A-E, each group having nine rats. Group A received normal saline; group B received 6.88 mg/kg of nicotine intraperitoneally (i.p); group C received 6.88 mg/kg of nicotine i.p. and 200 mg/kg of Moringa oleifera leaf powder dissolved in 2 ml of normal saline (orally); group D received 13.76 mg/kg of nicotine i.p., while group E received 13.76 mg/kg of nicotine i.p. and 200 mg/kg of Moringa oleifera leaf powder dissolved in 2 ml of normal saline (orally). Treatment was for 8 days and the rats were sacrificed after 24 hours of termination of study. Intracardial blood specimens were obtained to analyse blood glucose, while the pancreas was excised and either fixed in 4% paraformaldehyde for histology or sucrose solution and homogenised for biochemical analysis of lactate dehydrogenase (LDH) and glucose-6-phosphate dehydrogenase (G-6-PDH) enzymes. Results: In comparison with the Control, animals treated with low dose of nicotine with or without Moringa oleifera and those treated with high dose of nicotine plus Moringa oleifera had reduction in body weights (p>0.05), while marked reduction in pancreatic weights was noted in low dose nicotine (p<0.05) and both nicotine groups co-treated with Moringa oleifera (p<0.05). There were no significant changes in the levels of blood glucose and pancreatic G-6-PDH levels, while significant reduction occurred in pancreatic LDH levels in nicotine-treated rats (p<0.05). However, LDH improved following co administration with Moringa oleifera. Observation of the histology of the pancreas revealed atrophy of intercalated ducts, poorly delineated and disintegrating islet of Langerhans in animals treated with the higher dose of nicotine, while changes in pancreatic tissue in animals co-treated with Moringa oleifera were not as severe as the nicotine-treated animals. Conclusion: Moringa oleifera leaf decoction minimally ameliorates morphological and biochemical changes associated with nicotine-induced pancreatic damage. Keywords: Nicotine, Pancreatic damage, Moringa oleifera
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    Prenatal exposure to gestational nicotine before neurulation is detrimental to neurodevelopment of Wistar rats’ offspring
    (Universiti Sains Malaysia, Kelantan, 2018) Omotoso G.O.; Kadir R.E.; Sulaimon F.A.; Jaji-Sulaimon R.; Gbadamosi I.T.
    Background and aim: This study aimed to determine the effect of gestational nicotine exposure before neurodevelopment on the morphology and histology of the prefrontal cortex (PFC) in rats. Methodology: Adult female Wistar rats were time-mated and grouped into three categories: (a) control–given 0.1 mL of normal saline, (b) low-dose nicotine–given 6.88 mg/ kg/d/0.05 mL, and (c) high-dose nicotine–given 13.76 mg/kg/d/0.1 mL in two divided doses. Treatment was given intraperitoneally from gestational days 2 to 6. On postnatal day 15 (P15), the pups were separated from their mothers, anaesthetised and sacrificed, followed by intracardial perfusion with 4% paraformaldehyde. PFC was excised from the brain and processed for tissue histology, histochemistry, and morphology of brain cells. Results: Gestational nicotine exposure during the first week of gestation in rats significantly reduced birth weights in nicotine-treated groups compared with control; it, however, accelerated body weights, altered neuronal morphology, and elevated astrocytic count significantly, while oligodendroglial count was slightly increased in the PFC of juvenile rats examined at P15. Conclusion: These alterations revealed that gestational nicotine exposure before the commencement of the cellular processes involved in brain development negatively affects neurodevelopment, and this could result in neurological dysfunctions in later life.