Browsing by Author "Sulaiman, Faoziyat Adenike"
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Item Assessment of Environmental Factors on Secondary Metabolites and Toxicological Effects of Datura metel Leaves Extracts(Annals of science and Technology (AST), 2018) Abdul, Raheem; Adenike, Modinah Oladayo; Sulaiman, Faoziyat Adenike; Ahmad, Olatunde Abdulrahim; Halimat Amin, Yusuf; Olaniyi, Kamil; Mukadam, Abdulrahman Abdullah; Ganiya, Latifat Oluwatobi; Kamilu, Ahmed Lateef; Oladepo, Khadijat Busola Alimi; Grace, Oluwakemi; Afolayan, Daniel; Odeniran, TaiwoThis study evaluated the chemical composition, physicochemical properties, toxicological and environmental potentials of the Datura metel (D. metel) leaves extracts. Fresh leaves of D. metel were harvested at three different times of the day (morning, afternoon and evening), extraction done in succession using n-hexane and ethanol solvents respectively. Preliminary phytochemical screening, physicochemical analysis for specific gravity, pH, colour, total ash and moisture contents of the dried extracts were determined. The characterisation of the bioactive compounds using Gas Chromatography-Mass Spectrometry, showed the presence of different compounds at the three different times of the day, out of which phytol and 9,12,15-octadecatrienoic acid were present at all times. These results confirmed that some bioactive compounds present in this plant are dependent on environmental factor , time of harvest and the choice of solvent used while the presence of others are independent on these factors. Each extract was administered orally to Wistar rats for two weeks. There were significant difference (p < 0.05) in activities of AST (serum and heart), ALT (liver and serum) and ALP (Serum, liver and kidney), as well as the concentrations of albumin and protein in the liver and serum and urea in the serum of experimental rats given n-hexane and ethanolic extracts of D. metel. Generally it also suggest that the leaf extracts collected at three different times of the day had some significant toxicological effect, thus may not be totally safe for consumption at the dosage indicated since tissues membranes integrity of the Wistar rats were not potentially preserved.Item Inhibitory potential and drug-likeness of α-selinene from Syzygium aqueum, against Aromatase P450 P in breast carcinoma of Postmenopausal women: in silico study(aLAKANSE PUBLISHED, 2018) Alakanse, Oluwaseun Suleiman; Sulaiman, Faoziyat Adenike; Arannilewa, Abiodun Julius; Anjorin, Funmilola Favour; Malachi, Oluwaseyi Israel; Ayo, Ibukunoluwa Ebunolorun; Oladejo, Afees Adebayo; Oluwole, Olutekunbi Akinwumi; Olanrewaju, Opaleye Oyetola; Okeme, Usman; George, Ambrose Oche; Acho, Marvellous Amarachi; Oluwaseun, Oluwatosin Taofeek; Olufemi, Samuel Araoyinbo; Ayobamidele, Abass Bakare; Tolulope, Oluwafemi BolarinwaBreast cancer is the most diagnosed and prevalent cancer in women both in developed and developing countries, this constitutes a threat to the society and world economic stability. In situ carcinoma and invasive carcinoma are the broad rubric of breast cancer. In established breast carcinoma, about 80% depends on the gird of estrogen hormone for growth. Hence, the down-regulation of aromatase activities has been one of the strategies used in the treatment of breast-related carcinomas. This study explores Syzygium aqueum for the best drug-gable compound via computation tools. Seventy-one compounds were obtained from Syzygium aqueum plant which was retrieved from works of literature and were docked into the active site of aromatase p450 for their antagonistic effects. Α-selinene, the lead compound with the binding energy of -8.5 kcal/mol was obtained using PyRx, autodock vina tools used in the molecular docking to obtain the docking scores. To ensure and validate that the right target was used, the FASTA sequence of the crystalline structure of aromatase p450 was blast on the chembl database. Spearman rank correlation coefficient graph was plotted on graphpad prism 6 to obtain a strong correlation (R²) value of 0.77 between the dockings results of the CHEMBL’S compounds and their corresponding experimentally generated IC50 results. These results explain why α-selinene should be considered a potential antagonist of aromatase p450 in postmenopausal women suffering from breast carcinomas.