Browsing by Author "Simon, Nzikahyel"
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Item Solid-state synthesis of isostructural tetrachlorometallate salts of amodiaquine: crystal structure of [CdCl4][C20H24ClN3O](Springer, 2015-11-18) Tella, Adedibu C.; Owalude, Samson O.; Simon, Nzikahyel; Arise, Rotimi O.Tetrachlorometallate salts [AMDH2+][CoCl4]2- 1a and [AMDH2+][CdCl4]2- 2a (AMDH2+ = amodiaquine dication) were obtained by ball milling of amodiaquine with inorganic salts CoCl2.6H2O and CdCl2.6H2O, respectively, in the absence of solvent. Solution-based synthesis of [AMDH2+][CoCl4]2- 1b and [AMDH2+][CdCl4]2- 2b were also carried out by reaction of amodiaquine with the corresponding metal salts under reflux in methanol for 1 h. The analytical and spectroscopic data (IR, UV–Vis and NMR spectra) obtained for the compounds prepared via the two different routes are identical. The XPRD pattern of 1a closely matched the simulated pattern obtained from its reported single-crystal data. Single crystals of 2b suitable for X-ray structural analysis were obtained. The X-ray structure of 2b revealed an ionic compound with formula unit comprising of one protonated dicationic amodiaquine molecule and at etrachlorocadmate(II) anion. The crystals are triclinic with space group P-1 and unit dimensions a = 9.3272(8) A °, b = 11.1418(9) A ° , c = 12.482(10) A ° , V = 1191.89 A ° 3, and Z = 2. The amodiaquine molecule is protonated both at the quinoline and quinuclidine nitrogen atom. Antimalarial efficacy of 1a on Plasmodium berghei-infected mice were investigated, and the results revealed an enhanced activity of the compound by significantly (p\0.05) improving the suppression of parasitemia in established infection when compared with the controls.Item Synthesis, characterization, crystal structure and antimicrobial studies of a novel Cu(II) complex based on itaconic acid and nicotinamide(Elsevier B.V., 2016-07-12) Tella, Adedibu C.; Owalude, Samson O.; Ajibade, Peter A.; Simon, Nzikahyel; Olatunji, Sunday J.; Abdelbaky, Mohammed S.M.; Garcia-Granda, SantiagoA novel complex was synthesized from Cu(II), nicotinamide and itaconic acid and is formulated as [Cu(C5H4O4)2(C6H6N2O)2(H2O)2$2(H2O)] (1). The compound was characterized by elemental analysis, FTIR spectroscopy, UV-Vis and single crystal X-ray diffraction. The complex crystallizes in the triclinic P-1 space group, with a = 7.5111(2) Å, b = 9.8529(3) Å, c = 10.5118(4) Å, a = 116.244(3), b = 90.291(3)o, g = 103.335(3)o, V = 673.81(4) Å3, Z = 1.The octahedral geometry around the copper(II) ion is of the form CuN2O4 consisting of two molecules of nicotinamide acting as monodentate ligand through the nitrogen atoms, two molecules itaconate ligand and two coordinated water molecules each coordinating through the oxygen atoms. The structure of 1 showed infinite chains build up linking the molecules together via strong O-H....O and N - H....O intermolecular hydrogen bonds generating a two dimensional network sheet along c axis. The antimicrobial study of the synthesized complex 1 was investigated and showed higher antibacterial activity against all the organisms comparing with Copper(II) nicotinamide 2 and Copper(II) itaconate 3.Item Synthesis, thermal properties, and biological study of metal(II) nicotinamide complexes containing fumarate dianion and fumaric acid: Crystal structure of [Ni(H2O)4(nia)2](fum)·(H2fum)(Taylor and Francis, UK., 2017-02-28) Tella, Adedibu C.; Owalude, Samson O.; Mehlana, Gift; Olatunji, Sunday J.; Adetitun, David O.; Kolawole, Mathew O.; Simon, Nzikahyel; Alimi, Lukman O.New divalent transition metal nicotinamide (nia) complexes containing fumarate (fum) dianion and fumaric acid (H2fum), [M(H2O)4(nia)2](fum)¢(H2fum) [M = Co (1), Cu (2), and Ni (3)] have been synthesized. The compounds were characterized by elemental analyses, infrared, UV-vis, XRPD, and TGA. Structural analysis of 3 using single-crystal X-ray diffraction technique revealed that the Ni(II) ion is coordinated by four aqua and two nia ligands in an octahedral geometry. The structure of 3 is completed with fumarate (fum2¡) dianion acting as a counterion while fumaric acid (H2fum) is present as a molecule of solvation. The three complexes were investigated for biological activities.