Browsing by Author "Oyewopo AO"

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    CRYPTORCHIDISM AND HYPERTHERMIA-INDUCED TESTICULAR INJURY IN ADULT MALE RATS; INTERVENTION OF ALPHA TOCOPHEROL
    (An international journal published by the Society for Experimental Biology of Nigeria, 2023-03) Adunmo GO; Lawal AZ; Oyewopo AO; Oyewopo CI; Stephen DA; Akindehin OA; Adunfe OO; Adeleke OS; Hamzat FO; Ashamu EA
    The objective of this study is to determine the effects of cryptorchidism and hyperthermia on the testicular cytoarchitecture of adult male rats, quality and quantity of semen and the level of oxidative stress in the testes before and after intervention of Alpha-tocopherol (Vitamin E). Twenty-four (24) adult Wistar rats were used for this experiment and they were divided into seven groups (n=4). Experimental 1 cryptorchidism was carried out in some animals while others were subjected to hyperthermia from two sources (hot oven and light bulb) for 28 days; followed by intervention of 100mg/kg alpha-tocopherol for fourteen (14) days. All animals were then euthanized under anaesthesia. The testes were excised and fixed and processed using haematoxylin and eosin technique. Plasma was assayed for glutathione, superoxide dismutase (SOD) and malondialdehyde (MDA). Cryptorchidism and hyperthermia caused in cycto-architectural distortion in the testicular structures of exposed animals and significant reductions in caudal epididymal sperm count and motility, morphology and life and death ratio. Plasma SOD and GLU levels also reduced significantly in exposed animals while MDA levels increased significantly, indicating peroxidation of testicular tissue. Alpha-tocopherol due to its anti-oxidative properties impeded lipoperoxidation of the membrane, conserving cell union and increasing the amount of germ cells in the seminiferous epithelium. At doses and durations tested, alpha-tocopherol (αT) reverted to a significant extent the effects of cryptorchidism and hyperthermia by reducing apoptosis in germ cells, promoting cell survival and reducing histological alterations to the seminiferous epithelium. Keywords: Cryptorchidism, hyperthermia and Alpha-tocopherol
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    DETERMINATION OF STATURE FROM CEPHALIC INDICES AMONG OKUN AND EBIRA ETHNIC GROUPS OF KOGI STATE IN NIGERIA.
    (Department of Anatomy, Faculty of Basic Medical Sciences, University of Ilorin., 2019) Alabi AS,; Adeleye JT,; Kareem SB,; Lewu FS,; Oyewopo AO
    Cephalic index is an important feature that characterizes different races. The study aimed at comparing the cephalic indices between the two genders and to determine the stature among Okun and Ebira ethnic groups in Nigeria. The subjects were measured for cephalic length, breadth and subject height and the cephalic indices were calculated by dividing the cephalic breadth by cephalic length, and then multiply by 100. 844 subjects of Okun and Ebira origin of Kogi state were measured, 211 males and 211 femalesfor each tribe were measured. Fischer’s formula was used to determine the sample size because the population size is > 10,000. The cephalic breadth and length was measured using a spreading caliper and the subject height was measured with a stadiometer. The data was analyzed using Pearson’s Chi square analysis test for association, trends and distribution difference of the pattern (confidence level at 95%). The mean cephalic indices of both Okun and Ebira ethnic group were >75 and >70 which belongs to mesocephalic and doliocephalic group respectively. There were significant differences in cephalic indices between both ethnic groups (p<0.001). There was no significant difference in cephalic indices between males and females of each ethnic group. Stature was better predicted from cephalic indices for Ebira males (r= 0.386) when compared to the Ebira females (r= 0.127), Okun males (r= 0.296) and Okun females (r = 0.268). All predictions were significant except for Ebira females