Browsing by Author "Oyewopo, A. O."

Now showing 1 - 4 of 4
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    Anticancer effects of Morinda lucida and Annona muricata on immunomodulations of Melatonin, tumor necrosis factor-alpha and p53 concentrations in lead acetate-induced toxicity in rats
    (Qassim University, 2021-07) Akinlolu, A. A.; Ameen, M. O.; Oyewopo, A. O.; Kadir, R. E.; Ahialaka, O.; Tijani, S.; Ogungbesan, O.; Bebeyi, R.; Adebayo, S.; Amoo, T.; Abdulazeez, M.
    Objectives: Lead poisoning accounts for about 0.6% of global burden of disease. Lead-induced toxicity is through confinement of oxidative stress in affected organs. We evaluated the effects of MLF1 (extracted from Morinda lucida leaves) and AMF1 (extracted from Annona muricata leaves) on lipid peroxidation and immunomodulations of Melatonin, tumor necrosis factor-alpha (TNF-α), and p53 proteins in lead acetate (LA)-induced toxicity in rats. Methods: Sixty adult female rats were randomly divided into 12 groups (n = 5). Groups 1 and 2 received physiological saline and 100 mg/kg bodyweight of LA, respectively, for 5 weeks. Groups 3–6 received 100 mg/kg bodyweight LA for 2 weeks, followed by treatments with 7.5 and 15 mg/kg bodyweight of MLF1, and 7.5 and 10 mg/kg bodyweight of AMF1, respectively, for 3 weeks. Groups 7–10 received 7.5 and 15 mg/kg bodyweight of MLF1, 7.5 and 10 mg/kg bodyweight of AMF1, respectively, for 5 weeks. Groups 11–12 received co-administrations of 100 mg/kg bodyweight LA with 15 mg/kg bodyweight MLF1 and 10 mg/kg bodyweight of AMF1, respectively, for 5 weeks. Drugs and extracts were administered orally. Consequently, liver histopathology (Hematoxylin and Eosin), sera Melatonin, and TNF-α (enzyme-linked immunosorbent assay [ELISA]) levels were evaluated. Malondialdehyde (MDA) (thiobarbituric acid assay) and p53 (ELISA) levels were evaluated in liver homogenates. Data were statistically analyzed (P ≤ 0.05). Results: Results showed normal liver histology in all Groups. Statistical analyses showed significant (P ≤ 0.05) and non-significant decreased levels (P ≥ 0.05) of MDA, TNF-α and p53 in Groups 3-12, compared with Group 2. Furthermore, results showed significant (P ≤ 0.05) and non-significant increased Melatonin levels (P ≥ 0.05) in Groups 4–12 compared with Group 2. Conclusion: This study confirmed that MLF1 and AMF1 confer a degree of antioxidant, anticancer and hepato-protetive potentials against LA-induced toxicity in rats.
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    Moringa oleifera and Musa sapientum ameliorated 7,12-Dimethylbenz[a]anthracene-induced upregulations of Ki67 and multidrug resistance 1 genes in rats
    (Qassim University, 2021-05) Akinlolu, A. A.; Oyewopo, A. O.; Kadir, R. E.; Lawal, A.; Ademiloye, J.; Jubril, A.; Ameen, M. O.; Ebito, G. E.
    Objectives: Moringa oleifera (MO) and Musa sapientum (MS) are plants of ethnomedicinal importance. We evaluated the effects of MOF6 (extracted from MO leaves) and MSF1 (extracted from MS suckers) on immunomodulations of Ki67 (proliferation biomarker) and multidrug resistance 1 (MDR1) genes in the liver of rats in 7,12-Dimethylbenz[a]anthracene (DMBA)-induced hepatotoxicity and mutagenesis to determine their antiproliferation, anti-drug resistance, and anticancer potentials. Methods: Forty-five adult male rats were randomly divided into nine groups (n = 5). Groups 1 and 2 received physiological saline and 15 mg/kg bodyweight of DMBA, respectively. Groups 3 and 4 received 15 mg/kg bodyweight DMBA and were treated with 15 and 30 mg/kg bodyweight of MOF6, respectively. Group 5 received 15 mg/kg bodyweight DMBA and was treated with 10 mg/kg bodyweight of MSF1. Group 6 received 15 mg/kg bodyweight DMBA and was treated with 3.35 mg/kg bodyweight of doxorubicin and intravenous injection of 0.5 ml/200 g of cisplatin. Groups 7–9 received only 15 and 30 mg/kg bodyweight of MOF6 and 10 mg/kg bodyweight of MSF1, respectively. DMBA, doxorubicin, and extracts doses were administered orally. The duration of our experimental procedure was 8 weeks. Consequently, liver histopathology (hematoxylin and eosin technique) and enzyme-linked immunosorbent assay homogenates’ concentrations of Ki67 and MDR1 were evaluated. Computed data were statistically analyzed (P ≤ 0.05). Results: Results showed normal histoarchitectures of the liver in all groups. Statistical analyses showed significant (P ≤ 0.05) and non-significant decreased concentrations (P ≥ 0.05) of Ki67 and MDR1 in Groups 3–9 compared with Group 2. Therefore, MOF6 and MSF1 ameliorated DMBA-induced hepatotoxicity, abnormal proliferation, and drug resistance. Conclusion: MOF6 and MSF1 possess antiproliferation, anti-drug resistance, and anticancer potentials.
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    Radiological assessment of the calcaneal angles of Kwara populace: A retrospective study.
    (Publication of Journal of Jagadguru Sri Shivarathreeshwara University, Mysore., 2020) Alabi, A. S.; Mohammed, B. E.; Lewu, F. S.; Neku, O. R.; Kareem, S. B.; Oyewopo, A. O.; Adigun, F. M.
    INTRODUCTION: Estimation of sex from different dimensions has considerable forensic value, for the identification of human remains, in the estimation of sex at disaster sites and in corroborating reports from scientists. This study evaluated calcaneal angles of Kwara populace and estimated sex using X‑ray (Bohler’s angle [BA], crucial angle of Gissane [CG], Fowler–Philips angle [FPA], calcaneal inclination angle [CIA], and calcaneal compression angle [CCA]). MATERIALS AND METHODS: One hundred and ten lateral radiographs consisting of 59 males and 51 females (unilateral) were used in this study. The study was carried out on randomly collected lateral calcaneal radiographs of adults in several hospitals in Kwara state. Standard anthropometric methods were used to measure the right and left calcaneal angles: BA, GA, FPA, CIA, and CCA. Data were analyzed using SPSS version 23 (IBM® Armonk, New York, USA) statistical software. Confidence level was set at 95% as P ≤ 0.05 was considered statistically significant. RESULTS: For right and left calcaneus in both sexes, the calcaneal angles were not significant. The P value was >0.05 (P > 0.05), indicating a nonstatistically significant values for the calcaneal angles. This present study, following measurements of calcaneal parameters in determining the sex of the right and left foot, showed no significant statistical difference across all five parameters. CONCLUSION: The findings showed that the measured calcaneal parameters cannot be used for determining sex.
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    RELATIONSHIP BETWEEN FOOT LENGTH, BODY MASS INDEX, AND HEIGHT IN COMPARISON WITH PHALLUS LENGTH AMONG HEALTHY YOUNG NIGERIAN MEN
    (15. Published by Era's Lucknow Medical College & Hospital, Lucknow in association with American University of Barbados., 2019) Alabi, A. S.; Ogungbesan, A. A.; Lewu, F. S.; Kareem, S. B.; Oyewopo, A. O.; Adeleke, O. S.; Aigbogun, E. J.
    Most men have misleading information about the normal penis length so they get depressed thinking what they have is small and most go as far as doing surgery to try increasing the length. The aim of this study was to determine the average penile length and investigate the relationship between penile length and somatometric parameters in a group of healthy Nigerian men. A total of 200 healthy men were included in the study. The age, height and weight of the subjects were recorded. Penile length was measure in flaccid state. The correlation between penile length and somatometric parameters was analyzed by Pearson s analysis. The mean age of the subjects was 22.51±2.97 years. The mean penile length in flaccid states was 10.5±0.09cm. There was a weak positive correlation found between penile length and height, weight, and Body mass index respectively (P≤0.001, for all). The penile length must be known to be able to determine the abnormal penile sizes and to make convenient decisions in the counseling and treatment of people with short penis concern. These results demonstrate that somatometric parameters are correlated with penile length. We believe that further studies would provide more information about the casual relationship