Browsing by Author "Owoyele, B. V.,"

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    Effect of garcina kola seed on plasma C-reactive protein in human subjects
    (The Nigerian Journal of Pure & Applied Sciences,, 2013) Owoyele, B. V.,; Oyewole, A.L.; Amuda, O.,; Abioye, A.; Biliaminu, S. A.
    Garcinia kola seed ( Garcinia afzelii; also called bitter kola seed) i s a common .Africa snack fruit from a species of flowering plant in the Guttiferae family. Over the years, Africa traditional medicine and ethino pharmacology have attached invaluable roles to Garcinia kola seed (GKS) as a potent anti­hepatotoxic, anti-diabetic. antioxidant and antilisterial. To consolidate these roles. we focus our study on the effect of GKS on C-reactive protein (CRP) in human subjects. Sixty students voluntccrs (n=60 30 female & 30 male) from Faculty of Basic Medical Sciences. U nivcrsl ty of I lorin. N igeria. were used for this study. The screened voluntccrs were subjected to an hour rest for acclitnatization. This was follow by collection of about 2.5 ml of blood through venc puncture. The subjects were then asked to ingest 100 mg/k g of GKS and after 6 hours, another 2.5 ml of blood sample was collected from each subject. The level of C'RP was assay in the two sets of blood samples. The result shows 66.31%, significant decrease in the mean level of basal CRP of the female (p< 0.05). Contrast to this, inmale, there is 72.2 7% signi ficant increase from the mean level of basal CRP (p < 0.05). In conclusion. this study shows GKS as a potent anti-in flammatory fruit for female suhjects but not for male subjects. GKS anti-inflammatory effects are thus gender based. With these observations. it can be said to be more beneficial to female but not to male subjects . Lastly. the clinical practse or using CRP level in the blood to predict the pathogenesis of a disease, track of a disease progress or measure of effcct iveness of a treatment will be mislcading in habitual GKS consuming pati ents.
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    Effect of taurine and caffeine on spatial memory in adult male Wistar rats.
    (Neuroscience Society of Nigeria., 2017) Owoyele, B. V.,; Alashi, Y.; Oyewole, A.L.
    There is an increase in the production and consumption of caffeine and taurine beverages tagged as energy drinks. This study was therefore undertaken to investigate the effect of co-administration of caffeine and taurine on memory in Wistar rats. Fifty-four adult Wistar rats were divided into nine groups of six animals and treatments were as follows: Group 1 (10 ml/kg normal saline), Group 2 (100 mg/kg taurine), Group 3 (200 mg/kg taurine), Group 4 (taurine plus furosemide; 20 mg/kg), Group 5 (taurine plus nifedipine; 10 mg/kg), Group 6 (taurine plus caffeine), Group 7 (7.5 mg/kg caffeine), Group 8 (15 mg/kg caffeine) and Group 9 (taurine plus nifedipine plus furosemide plus caffeine). Treatment was once daily for 21 days, after which long term spatial memory of pretreatment training in Morris Water Maze was tested. Histological study was done using haematoxylin and eosin stains on hippocampus tissues harvested from the brain of one animal in each group. The results showed that there was a significant (p<0.05) decrease in time taken to find and mount the escape platform compared with the control. This was with the exception of the group co-treated with caffeine and taurine. Histological studies showed normal cell morphology, arrangement and distribution in the hippocampus. There was increased in the number of cells in the hippocampus of the animals given taurine (200 mg/kg) plus caffeine (15 mg/kg), and caffeine (15 mg/kg). In conclusion, at the doses used, co-administration of caffeine and taurine has no significant effects on spatial memory, however the separate use of caffeine or taurine proved to have capacity to enhance spatial memory