Browsing by Author "Owoyele, B. V."

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    EFFECTS OF THE ETHANOLIC EXTRACT OF BULBOSTYLIS COLEOTRICHA (HOCHST.EXA. RICH.) ON INFLAMMATION IN ADULT WISTAR RATS
    (Nigerian Society of Pharmacognosy, 2015-06-20) Owoyele, B. V.; Abioye, A. I. R.; Oyewole, A. L.; Ameen, Mubarak; Owemidu, I. O.; Adewusi, M. O.
    Bulbostylis coleotricha (family Cyperaceae) is a stem-tufted plant found in tropical region of Africa. It is locally used in treating various ailments among the African folks. Despite the high esteem this plant is held in Africa, there is dearth of scientific studies on B. coleotricha. This, in addition to the alarming increase in inflammatory diseases around the world, makes the present study to focus on the effect of the B. coleotricha extract on laboratory induced inflammation. Twenty-five adult Wistar rats, weighing between 225-287g were used for this experiment, and were randomly divided into five groups of five rats per group. The groups were labelled and treated as follow: Group 1, the negative control group, was treated with 10 ml/kg body weight (b. w.) of distilled water.Groups 2, 3 and 4, the treated groups, were treated with 25 mg, 50 mg and 100 mg/kg b. w. of ethanolic extract of B. coleotricha respectively. Doses were based on the local information on B. coleotricha usages. Group 5, the positive control group, was treated with 5mg/kg b. w. of indomethacin. In all the groups, the effects of all treatments were checked on induced inflammation using cotton pellet granuloma and carrageenan induced paw oedema model.The results in the two models used showed that ethanolic extract of B. coleotricha significantly inhibited inflammation in the treated groups. In the cotton pellet granuloma test the extract at the dose of 100 mg reduced granuloma formation from 30.2 ± 2.4 mg to 11.2 ± 2.6 mg reduced paw oedema from 7.0 ± 1.7 mm to 2.4 ± 0.8 mm (control is 100 mg/kg). In conclusion, this study established that Bulbostylis coleotricha plant is effective in the treatment of inflammation and can be explored in the treatment of various diseases with underlying inflammation.
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    Haemoglobin has no influence on pain perception of undergraduate students in Ilorin, North-Central, Nigeria
    (African Science Publications, 2024-10-21) Jimoh-Abdulghaffaar, H. O.; Olaniyan, O. E.; Jimoh, O. S.; Ananias, E. N.; Owoyele, B. V.
    Pain perception is influenced by various factors, including genetics, awareness, age, gender, and environmental factors (Hussain and Karim, 2019). This study aimed to determine if hemoglobin genotype variability affects human perception of pain. 208 participants aged 17-45 years from the University of Ilorin were recruited using purposive sampling. The participants were counselled and verbal consent was gotten from them before the procedure. Pain threshold and tolerance were assessed using the cold pressor test. 5mls of blood was drawn from antecubital vein and stored in Ethylenediamine tetraacetic acid (EDTA) bottles at 2⁰-6⁰C until hemoglobin electrophoresis was carried out. Data were analyzed using SPSS version 28.0 and presented as mean ± SD, median IQR, frequency as well as percentages and p-value < 0.05 was considered statistically significant. Sociodemographic results showed that 2.4% of participants were older than 35 years, 97.6% are unmarried and 85.6% are Yoruba. Hemoglobin electrophoresis revealed that 64% of participants were HbAA, 28.8% HbAS, 4.8% HbSS, and 2.4% HbAC. No significant variation was found in pain threshold between genotypes, though participants with the HbAS genotype had the highest pain threshold and the lowest pain tolerance, this warrants further investigation in larger sample. Higher pain threshold and tolerance may be conferred by HbS and HbC characteristics.
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    Nig. J. Nat. Prod. and Med.
    (Nigerian Society of Pharmacognosy, 2015-05-01) Owoyele, B. V.; Abioye, A. I. R.; Oyewole, A. L.; Ameen, M. O.; Owemidu, I. O.; Adewusi, M. O.
    Bulbostylis coleotricha (family Cyperaceae) is a stem-tufted plant found in tropical region of Africa. It is locally used in treating various ailments among the African folks. Despite the high esteem this plant is held in Africa, there is dearth of scientific studies on B. coleotricha. This, in addition to the alarming increase in inflammatory diseases around the world, makes the present study to focus on the effect of the B. coleotricha extract on laboratory induced inflammation. Twenty-five adult Wistar rats, weighing between 225-287g were used for this experiment, and were randomly divided into five groups of five rats per group. The groups were labelled and treated as follow: Group 1, the negative control group, was treated with 10 ml/kg body weight (b. w.) of distilled water.Groups 2, 3 and 4, the treated groups, were treated with 25 mg, 50 mg and 100 mg/kg b. w. of ethanolic extract of B. coleotricha respectively. Doses were based on the local information on B. coleotricha usages. Group 5, the positive control group, was treated with 5mg/kg b. w. of indomethacin. In all the groups, the effects of all treatments were checked on induced inflammation using cotton pellet granuloma and carrageenan induced paw oedema model.The results in the two models used showed that ethanolic extract of B. coleotricha significantly inhibited inflammation in the treated groups. In the cotton pellet granuloma test the extract at the dose of 100 mg reduced granuloma formation from 30.2 ± 2.4 mg to 11.2 ± 2.6 mg reduced paw oedema from 7.0 ± 1.7 mm to 2.4 ± 0.8 mm (control is 100 mg/kg). In conclusion, this study established that Bulbostylis coleotricha plant is effective in the treatment of inflammation and can be explored in the treatment of various diseases with underlying inflammation