Browsing by Author "Otohinoyi, D.A"

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    Cypermethrin and chlorpyrifos raises serum urea level and causes abnormal sperm morphology in Wistar rats
    (Biointerface Research in Applied Chemistry, 2019) Iyiola, Oluyinka Ajobola; Sulaiman, A.F; Sulaiman, Abdulfattah Afolabi; Anifowoshe, Abass Toba; Akolade, Jubril Olayinka; Adisa, Muhammad Jamiu; Otohinoyi, D.A; Rotimi, Damilare E.; Batiha, Gaber El-Saber; Maimako, Rotdelmwa Filibus; Adeyemi, O.S
    Chlorpyrifos (organophosphate) and cypermethrin (pyrethroid) are insecticides, which are widely used for agricultural as well as for domestic purposes. This study investigated the toxicological effect of chlorpyrifos and cypermethrin on selected organs and tissues of male Wistar rats. Nine (9) male Wistar rats were randomly grouped into three and were orally given chlorpyrifos or cypermethrin, while the control group was given distilled water for 28 days. The results revealed a significant increase (p<0.05) in rat serum AST activity for the chlorpyrifos and cypermethrin groups. Also, there was significant elevation in serum urea following oral exposure to either chlorpyrifos or cypermethrin. Conversely, a reduction in the rat liver ALP activity for treatment with cypermethrin or chlorpyrifos was recorded. The histology results revealed that the administration of chlorpyrifos but not cypermethrin for 28 days has no significant effect on the biochemical properties and sperm morphology of the rats. Taken together, findings indicate that cypermethrin and chlorpyrifos exposure in rats predisposes to renal injury, while altering sperm morphology.
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    Modulation of rat serum lipid profile and nephrotic indices following oral exposure to the extracts of chilli pepper
    (EurAsian Journal of BioSciences Eurasia J Biosci, 2019) Sulaiman, F.A; Yusuf, B.O; Omar, S.A; Muritala, H.T; Adisa, M.J; Olopade, A.A; Babajamu, F.I; Jimba, A.T; Babatunde, A.L; Adeniyi, B.A; Opaleye, B.R; Maimako, R.F; Otohinoyi, D.A; Bello, O.K; Rotimi, D; Olaolu, T.D; Nwonuma, C.O; Alejolowo, O.O; Batiha, G.E; osemwegie, O.O; Adeyemi, O.S
    Background: The increasing application of plants for medicinal purposes necessitates safety/toxicity profiling. Objective: In the present study, we evaluated the toxicological effects of the ethanolic extracts of the leaves (CAL), root (CAR) and stem (CAS) of Capsicum annuum in rats. Methods: Male Wistar rats were randomly assigned groups and given oral administration of the extracts or distilled water for 28 days. Results: Data showed that administration of ethanolic extracts of CAL, CAR and CAS did alter the liver function indices but not in a clear-cut manner to suggest hepatotoxicity. The CAR and CAS extracts decreased (p<0.05) the rat serum albumin levels compared with the control. In contrast, CAL extracts raised (p<0.05) the rat serum albumin level relative to the control. The plant extract administration raised rat serum bilirubin level compared with the control. Further, the extracts caused reduction (p<0.05) in rat serum TAG levels compared with the control. The CAL, CAR and CAS extracts did not significantly affect the rat serum creatinine level, but caused significant elevation of rat serum urea compared with the control. Conclusion: Taken together, findings do not only support the cardio-protective potential of C. annuum extracts, but implicate the nephrotoxic tendency of the plant extracts.