Browsing by Author "Opabunmi, E. T."

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    Protective Potential of Thymoquinone on Cyclophosphamide-Induced Hepatotoxicity in Rat
    (National Association of Specialist Medical Doctors in Academics in Nigeria, 2022) Adana M. Y.; Opabunmi, E. T.; Sunmonu, O. E.; Bello, A. A.; Onigbolabi, O. G.; Imam A.; Ajao, M. S.
    Background: Cyclophosphamide (CYC) has been known as an anticancer drug with several side effects on various organs such as the liver. In this study, the hepatoprotective properties of thymoquinone (TQ) were tested to decrease the damaging effects of Cyclophosphamide on the liver. Objective: To study and observe the possible ameliorative effect of thymoquinone on cyclophosphamide-induced hepatic toxicity in Wistar rats. Methods: Thirty Wistar male Adolescent (8 – 9 weeks old) rats weighing 70g – 150g were divided into Six groups; 5 rats per group (n=5) and treated orally for 21 consecutive days. Group A served as the control, and the rats in this group received normal saline. Group B was treated with 20mg/kg of cyclophosphamide. Group C was treated with 5mg/kg of Thymoquinone. Group D was treated with 10mg/kg of Thymoquinone. Group E was treated with 20mg/kg of cyclophosphamide and 5m/kg of Thymoquinone while Group F animals were treated with 20mg/kg of Cyclophosphamide and 10mg/kg of Thymoquinone. Results: The Cyclophosphamide treated group showed significant decreases in the body and liver weight, distorted hepatic cytoarchitecture, and reduction in hepatic function whereas co-treatment with TQ, showed protective effects on Cyclophosphamide-induced hepatotoxicity damage. Conclusion: These results suggest that the administration of Thymoquinone may have a protective potential on Cyclophosphamide induced hepatotoxicity.