Browsing by Author "Onigbolabi O.G."

Now showing 1 - 2 of 2
  • Item
    Castor oil induces morphological changes in endometrium and biochemical parameters in pregnant Wistar rats
    (Association of Medical Doctors in Academics, 2021) Kadir E.R.; Ibrahim A.; Imam A.; Onigbolabi O.G.; Imam A.A.; Ajao M.S.
    Background: Misoprostol is a synthetic prostaglandin E1 analogue, used for the management of miscarriages and labour. Castor oil is a natural plant extract that has been reported to have some abortifacient Properties Objectives: This study investigated the labour induction and abortifacient properties of castor oil, as well as possible effects on the electrolytes and hormones that regulate pregnancy, as well as to compare these effects with a standard labour inducing drug misoprostol, in Wistar rats. Methods: The study was conducted out in 2 phases. The pregnant rats were administered varying Castor oil doses of low (12.4ml/kg), medium (18.6ml/kg) and high (24.8ml/kg), which were compared with misoprostol group as well as a control group. All animals were euthanized on gestational day 15 and day 20 respectively for the two phases and blood samples collected via cardiac puncture from the apex of the heart for hormonal assay, electrolyte and kidney function tests. The uterus was also removed for histological processing. Results: The abortifacient effect of castor oil is dose dependent with high dose castor oil group seen to have significantly reduced serum progesterone level (32.8±4.25 and 40.8±0.70 compared with 51.0±2.00 of controls), resulted in weight loss and interference with kidney function (increase in serum potassium while decrease in sodium electrolytes). Castor oil also exhibited labor inducing properties. Conclusion: Castor oil has the potential to induce abortion. This study has demonstrated a possible usage of castor oil in medical induction of labor in rats as it exerted uterotonic principle on the uterus.
  • Item
    Impact of Potassium Sorbate on Cognitive Performance and Hippocampal Morphology in Wistar Rats
    (The Society for Experimental and Clinical Anatomists of Nigeria, 2025) Adana M.Y.; Lawal K.; Onigbolabi O.G.; Akintola S.
    Background and aim: Potassium sorbate is commonly used as an antimicrobial preservative in oral and topical pharmaceutical formulations and is generally regarded as a relatively nontoxic substance by the US FDA. However, some adverse reactions to potassium sorbate have been reported. This research aimed to investigate the effects of potassium sorbate on the structure and function of the hippocampus in adult male Wistar rats. Materials and Methods: Twenty-five male Wistar rats, aged 8-10 weeks and weighing 180-220g, were randomly divided into five groups of five rats each. The groups included Group NS, which received normal saline; PS25, which received potassium sorbate at 25 mg/kg body weight; PS50, which received potassium sorbate at 50 mg/kg body weight; PS100, which received potassium sorbate at 100 mg/kg body weight; and PS200, which received potassium sorbate at 200 mg/kg body weight. All treatments were administered orally every day for 56 days. Histological, biochemical, and immunohistochemical methods were used to assess the structural and functional characteristics of the groups. The immunohistochemical localisation of GFAP (Glial Fibrillary Acidic Protein), NeuN (Neuronal Nuclear Protein), and BCL-2 (B-cell Lymphoma/Leukemia 2 Protein) was performed. Additionally, the effects on the animals’ behaviour were evaluated using behavioural tests. Results: The structure and expression of proteins in the hippocampus were dose-dependently distorted; however, no notable changes in learning and memory functions were observed in the animals. Conclusion: Potassium sorbate exhibits deleterious effects on the hippocampus of rats in a dose-dependent manner.