Browsing by Author "Omokanye, K.O."
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Item Clinico-Laboratory Features of Multiple Myeloma in Selected Patients at University of Ilorin Teaching Hospital, North Central Nigeria(University of Ilorin, 2019) Babatunde, A.S.; Durotoye, I.A.; Shittu, A.O.; Omokanye, K.O.; Ogunfemi, M.K.; Sanni, E. O.; Owoeye, O.A.Abstract Multiple myeloma is an haematological disorder characterized by clonal proliferation of bone marrow plasma cells with production of increased amounts of monoclonal immunoglobulins which are detectable in blood and/or urine. The aim of the study was to describe the clinical and laboratory characteristics as well as treatment outcome in multiple myeloma patients diagnosed and managed at the Haematology Department of the University of Ilorin Teaching Hospital (U.I.T.H), Ilorin, North Central Nigeria, between 1st January 2008 and 31st December 2018. The study materials included bone marrow registers from the department and case folders of all multiple myeloma patients diagnosed within the study period. Relevant data including socio-demographic characteristics of patients, clinical features at presentation and laboratory tests results were extracted, documented and analyzed. Diagnosis was made in all patients based on the presence of major and/or minor criteria as described by the International Myeloma Working Group guidelines. Fifty eight (58) patients were diagnosed with multiple myeloma comprising of 31 males and 27 females (M:F ratio = 1.15:1). The median age of patients was 62.6 years (range = 39 – 85 years), and the most common presenting features included back pains (86.2%), bone pains (69%), inability to walk (67.2%) and anaemia (67.2%). High erythrocyte sedimentation rate > 30mm/Hr was seen in all patients (100%), Immunoglobulin G (Ig G) was the commonest monoclonal immunoglobulin demonstrated on serum protein electrophoresis (82.8%), and “punched out” osteolytic bone lesion on X-rays was demonstrated in 79.3% of cases. In resource-limited settings such as ours, the diagnosis and monitoring of patients with multiple myeloma still rely on the clinical and laboratory features of the disease to a large extent, hence the need for haemato-oncologists and physicians to be conversant with these features.Item Clinico-Pathologic features and outcome of Chronic Lymphocytic Leukemia in Ilorin, North Central Nigeria(College of Health Sciences, University of Ilorin, 2020) Babatunde, A.S.; Durotoye, I.A.; Shittu, A.O.; Omokanye, K.O.; Ogunfemi, M.K.; Owoeye, O.A.; Sanni, E.O.Abstract: A retrospective analysis of all patients that were diagnosed and managed for Chronic lymphocytic Leukemia(CLL) in the Department of Haematology of University of Ilorin Teaching Hospital, Ilorin between 1st January 2005 and 31st December 2018 was carried out with the aim of characterizing the clinical, haematological and prognostic features as well as outcome in the patients. A total of 39 patients were reviewed consisting 25(64.1%) males and 14(35.9%) females giving a M:F ratio of 1.6:1. The median age of patients at diagnosis was 65.5 years and the highest prevalence was found in the 60 – 69 years age group. The commonest symptoms at presentation were night sweats (59.0%), Body weakness (51.3%), fever (41.0%), and weight loss (41.0%) while the commonest signs included lymphadenopathy in all patients (100%), splenomegaly (87.2%), pallor (53.9%) and hepatomegaly (46.2%). The mean values of haematological parameters were: Packed cell volume (28.6%), Haemoglobin concentration (9.4g/dL), Total white blood cell count (87.6 x 109/L), Absolute lymphocyte count (55.8 x 109/L) and platelet count (134.8 x 109/L). The majority of the patients (94.9%) were diagnosed with advanced disease (Rai stage III and IV) while only 2(5.1%) had Rai stage II and none in Rai stage 0 – I. Chlorambucil-based regimen was used in 71.8% of patients, and only 2 patients had Rituximab as part of their treatment regimen. The clinical presentation, haematological features and disease outcome observed in our study was similar to what had been reported in Nigeria and other parts of the world.Item Comparative Analysis of Baseline and One Year Post HAART Haematological Parameters in HIV Infected Patients in Ilorin, Nigeria(Sikkim Manipal University, 2017) Olawumi, H.O.; Babatunde, A.S.; Adepoju, A.M.; Omokanye, K.O.; Jayeola, A.A.; Ogunfemi, M.K.; Oladosu-Olayiwola, O.R.Abstract:Haematological abnormalities are common manifestations of HIV infection. The aim of this study was to determine the effect of HAART on haematological parameters of HIV infected patients.This was a longitudinal prospective study conducted at the HAART clinic of University of Ilorin Teaching Hospital, Ilorin. Eighty newly diagnosed HIV positive patients between 21-75 years who were planned to commence HAART (lamivudine, zidovudine and nevirapine) were recruited into this study. Baseline and one year post- HAART full blood count were carried out by Sysmex KX21 according to manufacturer’s instructions.Twenty nine percent of the patients had anaemia, 13% had neutropaenia and 0.02% had thrombocytopaenia at presentation. There was a significant increase in mean hemoglobin concentration of the patients from 10.79±1.89g/dl at baseline to 11.52±1.27g/dl at one year post HAART initiation. (P value=0.003) There was a statistically significant difference in mean baseline haemoglobin concentration of patients in WHO clinical stages 1, 2 and 3(11.67±1.39g/dl, 10.47±2.09g/dl, 10.00±1.86g/dl respectively; P=0.012). HIV patients were more likely to present with anaemia followed by neutropaenia and rarely thrombocytopaenia. Severity of anaemia increased with disease progression. HAART led to improvement in haematological abnormalities with significant increase in haemoglobin concentration. Haemoglobin concentration may therefore be used to monitor response to HAART in HIV infected patients.Item Evaluation of the Clinico-haematological Characteristics and Pattern of Presentation of Acute Myeloid Leukemia in Ilorin, North Central Nigeria.(Ambrose Alli University, Ekpoma, 2020) Babatunde, A.S.; Durotoye, I.A.; Shittu, A.O.; Omokanye, K.O.; Ogunfemi, M.K.; Owoeye, O.A.; Sanni, E.O.Acute myeloid leukemia (AML) is a malignant haematologicaldisorder of the myeloid lineage in the bone marrow resulting from clonal proliferation of haemopoietic progenitor cells with accumulation of myeloblasts in the blood, bone marrow and tissue infiltration. The aim of this retrospective study was to determine the pattern of presentation, clinical features and haematological parameters of AML patients diagnosed at the Haematology Department of U.I.T.H, Ilorin between 1" January 2008 and 31“ December 2018. The study materials included Bone marrow registers from the department and case folders of all AML patients diagnosed within the study period. Relevant data including socio-demographic characteristics of patients, clinical features at presentation and laboratory tests results were extracted, documented and analyzed. Diagnosis of AML was made based on the findings of 20% blasts in the bone marrow and/or peripheral blood and classified using FAB classification criteria.There were forty-six patients and their median age at diagnosis was 20.6 + 15.9 years.The highest prevalence of the disease was found in the 11 — 20 years age group.The most common presenting symptoms were fever (91.3%), pallor (84.8%), bleeding diasthesis (52.2%), and body weakness (45.7%).The mean+SD values of haematological parameters in the patients wer—e PCV (19.9+5.8%), Hb cone. (6.6+1.9 g/dL), Total WBC (48.1+54.8 x 10’/L) and Platelet Count (39.6+24.0 x 10’/L).The commonest subtype of AML in our study was M4 which was seen in 26 (56.5%) patients, followed by M5 observed in 10 (21.7%) patients. In resource-limited settings such as ours, the diagnosis and monitoring of patients with AML still rely on the clinical and laboratory features of the disease to a large extent, hence the need for Haemato-oncologists and Physicians to be conversant with these features.Item Evaluation of the Indications and Diagnostic Value of Bone Marrow Examination in Haematological Disorders in Ilorin Nigeria: A Review of 496 Cases(College of Health Sciences, University of Ilorin, 2020) Babatunde, A.S.; Durotoye, I.A.; Shittu, A.O.; Omokanye, K.O.; Ogunfemi, M.K; Owoeye, O.A.Abstract: Bone marrow examination, either in the form of aspiration or biopsy, is an invasive procedure which is relatively safe and is still being performed routinely in the investigation and diagnosis of various malignant and non-malignant haematological disorders. The aims of this study were to evaluate the role of bone marrow examination in the investigation and diagnosis of haematological disorders, and the pattern of disorders diagnosed by bone marrow examination in our centre. This study was a retrospective review of all cases of bone marrow examinations which were carried out at the Haematology department of U.I.T.H Ilorin between 1st January 2005 and 31st December 2018. Case folders of all patients who had bone marrow examination done during the study period, Bone marrow aspiration and biopsy registers from Haematology department, Bone marrow reports and Full blood counts (FBC) results were retrieved and analyzed. Relevant clinical information retrieved included age, gender, clinical features at presentation, laboratory investigations, treatment regimen, and survival outcome among others. A total of 496 cases had BME performed during the study period. The patients comprised 276 (55.8%) males and 220 (44.2%) females with a M:F ratio of 1.3:1. Their median age was 38.5 years (age range 16 months and 85 years). Pathological marrow with diagnosis on BME was found in 441 (88.9%) while normal marrow (negative for any pathologic condition) was seen in 55 (11.1%) of patients. The leukemias (acute and chronic) were the commonest haematological disorders found on bone marrow examination, constituting 37.8% of cases. Unexplained anaemia was the commonest clinical feature at presentation necessitating bone marrow examination. Bone marrow examination is still very useful as a diagnostic tool in the hand of Haematologists in the investigation and diagnosis of various haematological disorders, and is relatively safe to perform even with presence of thrombocytopenia.Item Evaluation of the Indications and Diagnostic Value of Bone Marrow Examination in Haematological Disorders in Ilorin Nigeria: A Review of 496 Cases.(College of Health Sciences, University of Ilorin., 2020) Babatunde, A.S.; Durotoye, I.A.; Shittu, A.O.; Omokanye, K.O.; Ogunfemi, M.K.; Owoeye, O.A.Abstract Bone marrow examination, either in the form of aspiration or biopsy, is an invasive procedure which is relatively safe and is still being performed routinely in the investigation and diagnosis of various malignant and non-malignant haematological disorders. The aims of this study were to evaluate the role of bone marrow examination in the investigation and diagnosis of haematological disorders, and the pattern of disorders diagnosed by bone marrow examination in our centre. This study was a retrospective review of all cases of bone marrow examinations which were carried out at the Haematology department of U.I.T.H Ilorin between 1st January 2005 and 31st December 2018. Case folders of all patients who had bone marrow examination done during the study period, Bone marrow aspiration and biopsy registers from Haematology department, Bone marrow reports and Full blood counts (FBC) results were retrieved and analyzed. Relevant clinical information retrieved included age, gender, clinical features at presentation, laboratory investigations, treatment regimen, and survival outcome among others. A total of 496 cases had BME performed during the study period. The patients comprised 276 (55.8%) males and 220 (44.2%) females with a M:F ratio of 1.3:1. Their median age was 38.5 years (age range 16 months and 85 years). Pathological marrow with diagnosis on BME was found in 441 (88.9%) while normal marrow (negative for any pathologic condition) was seen in 55 (11.1%) of patients. The leukemias (acute and chronic) were the commonest haematological disorders found on bone marrow examination, constituting 37.8% of cases. Unexplained anaemia was the commonest clinical feature at presentation necessitating bone marrow examination. Bone marrow examination is still very useful as a diagnostic tool in the hand of Haematologists in the investigation and diagnosis of various haematological disorders, and is relatively safe to perform even with presence of thrombocytopenia.Item Pattern of Haematological Changes in Patients with Chronic Kidney Disease Attending Nephrology Clinic in a Tertiary Hospital in North Central Nigeria(Amber Publication Ltd, 2020) Sanni, E.O.; Olawumi, H.O.; Durotoye, I.A.; Babatunde, A.S.; Shittu, A.O.; Biliaminu, S.A.; Omokanye, K.O.; Ogunfemi, M.K.; Akinwumi, O.O.; Oyedepo, D.; Dane, S.Introduction: The impact of the disease of the kidney is enormous in developing countries like Nigeria. With the increasing use of erythropoietin stimulating agents in anaemic patients with CKD, there is a need to evaluate the changes in haematological parameters in these patients. This study assessed the haematological changes in patients with known chronic kidney disease. Materials and methods: Our research was a cross-sectional study that assessed and compared the haematologic parameters of 113 patients who had established chronic kidney disease and 113 -healthy controls who were age–and sex-matched. The full blood count (FBC) was determined by SysmexKX21(Sysmex, Japan). The test of significance was set at a P- value of <0.05. Results and Discussion: The mean age of patients with CKD was 55.00 + 15.37 years, whilst that of controls was 52.73±13.59 years. (p-value 0.240) The values of the mean of the Hb and RBC among the patients were 9.69+ 2.25g/dl and 3.62 ± 0.92 x 1012/L respectively and were found to be significantly lower than that seen among controls (13.62 ± 1.45 and 4.94 ± 0.62 respectively) with a P-value<0.001. Significantly higher values of the mean WBC and platelet count were found in the patients when compared with the control participants (p-value<0.001). A significant proportion of our patients had microcytic hypochromic anaemia (32%). Conclusion: Careful evaluation of the cause of anaemia and urgent interventions are needed in the managements of these patients.Item Prevalence and Associated Risk Factors of Hepatitis B Virus Infection Among Healthcare Professionals in a Tertiary Care Hospital in Nigeria: A Cross Sectional Study(The Faculty of Basic Clinical Sciences, University of Medical Sciences, Ondo state, Nigeria, 2023) Suleiman, S.T.; Bojuwoye, Matthew Olumuyiwa; Idris, S.O.; Ogunfemi, M.K.; Omokanye, K.O.; Bello, A.H.; Omotoso, A.B.O; Ahmed, A; Oni, J.O.; Imran, J; Oyewopo, C.I.This study investigated the prevalence and risk factors of hepatitis B virus (HBV) infection among healthcare professionals (HCPs) in a tertiary care hospital in Nigeria. Of the 355 participants, 7.3% were infected with HBV, with nurses having a highest prevalence rate of7.2%. Multivariate analysis identified age group 30-39 and a history of needle-stick injury as independent risk factors for HBV infection. Only 40.3% of HCPs had received complete HBV vaccination, with 31.0% reporting incomplete vaccination and 28.2% having had no vaccination. The study highlights the importance of implementing comprehensive HBV vaccination programs and strict adherence to infection control guidelines to prevent occupational transmission of HBV among HCPs in Nigeria. The findings also emphasize the need for increased awareness of the risk factors associated with HBV infection among HCPs. These insight scan guide the development of effective public health policies aimed at reducing the burden of HBV infection in the healthcare sector