Browsing by Author "Omokanye, L.O"

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    Clomiphene resistant polycystic ovarian syndrome: Analysis of outcomes following laparoscopic ovarian drilling in infertile women in Ilorin, North-central, Nigeria
    (African Health Research Organization, 2017) Omokanye, L.O; Olatinwo, A.O; Pati, A; Ibrahim, S; Durowade, K.A; Oyedepo, O.O; Ige, O; Adegboye, M.B.
    Background: Laparoscopic ovarian drilling (LOD) is one-off treatment modality for clomiphene citrate (CC)-resistant polycystic ovarian syndrome (PCOS) avoiding the need of medical therapy and its attendant complications. Aims and Objectives: This study aimed at determining the efficacy of LOD in women with anovulatory infertility secondary to CC‑resistant PCOS and factors influencing reproductive outcomes. Materials and Methods: A cross-sectional study of infertile women who underwent LOD on account of CC-resistant PCOS between January 2012 and December 2015 at a tertiary institution. Results: Patients aged 24–38 years (29.7 ± 3.6 years) and their body mass index (BMI) ranges from 20 to 35 (26.3 ± 4.3). The majority (90.5%) were nulliparous. Most (61.3%) had primary infertility. Their duration of infertility ranges from 1 to 13 years (4.3 ± 2.7) and ovarian volume ranges from 10 to 24 cm3 (mean, right ovary = 15.2 ± 3.2; left ovary = 16.3 ± 3.2). The number of drills per ovary ranged from 4 to 14 (mean, right ovary = 7.4 ± 2.1; left ovary = 7.3 ± 2.1) and the luteinizing hormone/follicle stimulating hormone (LH)/FSH ratio ranges from 2 to 6 (3.2 ± 1.4). All achieved spontaneous resumption of menses and ovulation with mean durations of 4.0 ± 1.8 days and 5.3 ± 3.2 weeks, respectively. Eighty-three (60.6%) clinical pregnancies were recorded, of which 68 (49.6%) resulted to live births (61 singletons and 7 twin births) and 14 (10.2%) early first trimester miscarriages. The mean time interval from LOD to pregnancy was 4.4 ± 1.1 months. There was a significant association between BMI, duration of infertility, FSH/LH ratio, and pregnancy outcomes (P < 0.05). Conclusion: LOD is the most preferred treatment modality for CC-resistant PCOS as it resulted in higher pregnancy rate.
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    PREVALENCE, RISK FACTORS OF HUMAN PAPILLOMAVIRUS INFECTION AND PAPANICOLAOU SMEAR PATTERN AMONG WOMEN ATTENDING A TERTIARY HEALTH FACILITY IN SOUTH-WEST NIGERIA
    (Turkey Periodical of Gulhane Medical Faculty, Gulhane Medical Academy, 06019, Ankara, 2015) Kolawole, O.M; Olatunji, K.T; Durowade, K.A; Adeniyi, A.A; Omokanye, L.O
    Background: Cervical cancer amongst Nigerian women has been on the increase in the past decade, and is regarded as the second highest cause of cancer deaths among Nigerian women. Objective: This study was aimed at determining the prevalence, risk factors of HPV infection, and Papanicolaou smear pattern amongst a cohort of women attending the Gynaecology clinic of a tertiary health facility in Ido-Ekiti, South west Nigeria. Methodology: This was a cross-sectional study involving the screening of women between the ages of 15-64 years for cervical intraepithelial neoplasia using Papanicolaou smear staining technique and serological diagnosis using IgG enzyme linked immunosorbent assay kits. Respondents were selected through convenience sampling of subjects, while intervieweradministered questionnaire and clinical report form were also used to collect data, and data was analyzed using SPSS version 17. Result: Of the 200 blood samples examined for Human papillomavirus infection, 135 (67.5%) were sero-positive while 65 (32.5%) were sero-negative. For cervical cytology using Papanicolaou smear, 14 (7%) were positive (had presence of cervical abnormality) while 186 (93%) were negative (had no cervical abnormality). Result showed a direct relationship between seropositivity, development of cervical intraepithelial neoplasia and Human papillomavirus infection. The risk factors for the development of HPV infection included age, type of marriage, parity, history of genital infection and tobacco usage. Non circumcision of male partner was also found to be a risk factor. Conclusion: The presence of abnormal cervical cytology and high level of serological positivity clearly showed why there is need for a holistic approach to the screening, vaccination methodologies and early detection of HPV infection in the country.
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    Traditional eye pencil: A rural- urban comparison of pattern of uptake and association with glaucoma among adults in selected communities of North Central Nigeria
    (African Health Research Organization, 2017) Durowade, K.A; Salaudeen, A.G.; Musa, O.I; Olokoba, L.B; Omokanye, L.O; Akande, T.M