Browsing by Author "Oluyinka A. Iyiola"

Now showing 1 - 2 of 2
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    Comparative study of antidiarrheal potential and genotoxicity in mice exposed to corn, sorghum and millet steep liqours
    (Nigerian Society for Experimental Biology, 2016) Faoziyat A. Sulaiman; Oluyinka A. Iyiola; Muinat O. Kazeem; Abdulfattah A. Sulaiman; Amina M. Ahmed El Imam; Adisa M. Jimoh; Olaoluwa J. Ademola; Adekunle S. Babalola; Elizabeth O. Sunday-Nwaso
    In this study, the antidiarrheal, cytotoxic and genotoxic properties of sorghum, millet and corn steep liquors as well as mistletoe extract in wistar rats were investigated. Comparative analysis of antidiarrheal potentials of sorghum, millet and steep liqours with standard drug (loperamide) and oral rehydration solution (ORS) in a castor oil-induced diarrheal model was carried out. Blood was examined for serum biochemical parameters and genotoxic effects were investigated using micronucleus test. In the antidiarrheal test, the test agents showed action which was significant (P<0.05). Mistletoe extract exerted maximum inhibition (55.56 %) against defecation, whereas 44.44 % and 59.26 % inhibitions were obtained for ORS and loperamide respectively. The genotoxicity studies of these steep liquors and mistletoe extract revealed damage to the genetic material and alteration of the activities of some marker enzymes, which is indicative of tissue damage. Although sorghum, millet and corn steep liquors, as well as mistletoe
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    Induction of Micronuclei, Cellular Stress Response, and DNA Strand Breakage in Two Common Fish Species From Rivers and Reservoirs in Ilorin, Nigeria
    (2021-08-09) Abass Toba Anifowoshe; Segun Olayinka Oladipo; Arinola N Oyinloye; Augusta Opute; Edward Odon; Omotola Aiki; Moshood Y Abdulrahim; Kehinde Monica Akinseye; Saratu Iyabode Abdulkareem; Oluyinka A. Iyiola
    Indiscriminate discharge of home, agricultural, and industrial wastes into water bodies, most rivers and reservoirs around the world are becoming polluted. The ecotoxicological potential of this in sh species gathered from important reservoirs and rivers in Ilorin, Nigeria, was explored in this study. Unilorin reservoir, Asa reservoir, Apodu reservoir, Asa river (Unity), and Asa river (Unity) water samples were collected and physicochemical characteristics were investigated at ve distinct sites: Unilorin reservoir, Asa reservoir, Apodu reservoir, Asa river (Unity), and Asa river (Unity) (Harmony). In Tilapia zillii and Clarias gariepinus, we measured serum biochemical (AST, ALT, ALP, serum ALB), histopathological (gills, lungs), and serum antioxidant enzyme responses (SOD, CAT, GPx, GR, GST) as a biomarker for oxidative stress, while micronucleus and comet assays were used to detect DNA damage. Except for DO, which was very low in the two rivers, the physicochemical parameters and heavy metals evaluated in the ve separate water bodies were within the allowed levels of the NSDWQ and WHO standard for drinking water. In comparison to the Unilorin, Apodu, and Asa reservoirs, a slight increase in Pb was observed across the ve sampling sites, which could contribute to increased biochemical and haematological pro les, histopathological lesions in the gill and lungs, inductions of MN, NA, and DNA single strand break in T. zillii and C. gariepinus collected from Asa rivers. This could be due to the indiscriminate dumping of e uents from adjacent industries, agricultural wastes, and household wastes into rivers.