Browsing by Author "Oluwasola, A.,"
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Item Effect of prolonged heat exposure on red blood cell indices in-vivo among local bread bakers in Ilorin metropolitan city(Society of Basic and Applied Physiology, 2022) Ayinde, T.O.,; Oluwasola, A.,; Olohungbebe, K.A.,; Ojulari, L.S.,; Sanni, M.A.,; Afodun, A.M.,; Balogun, M.E.Background: Occupational hazards are specific dangers workers are exposed to, at work environments, due to tools, or interactions among co-workers. This is also seen among local bakers exposed to undue heat culminating into several unreported health conditions making the victims to indiscriminately and erroneously take blood supplements as antidotes. This study was conducted to explore the effect of prolonged environmental heat exposure on red blood cells indices in vivo among local bakers in Ilorin metropolitan city. Methodology: One hundred office workers and 100 local bread bakers with 5 years and above working exposure to prolonged heat were selected from 10 different local bakeries in Ilorin. Following completion of a questionnaire, blood samples were collected for assessment of red blood cell indices. Result: There was significant (p<0.05) increase in levels of haemoglobin, packed cell volume, and mean corpuscular haemoglobin, while there was no significant (p>0.05) change in the levels of RBC, MCV and MCHC, though there was increase. Conclusion: In conclusion, the result of this study demonstrated that prolonged heat exposure caused increase in the level of haemoglobin, packed cell volume, and mean corpuscular haemoglobin. However, red blood cell count, mean corpuscular volume, and mean corpuscular haemoglobin concentration of the bakery workers were uneventful compared to that of the control.Item Effect of prolonged heat exposure on red blood cell indices in-vivo among local bread bakers in Ilorin metropolitan city(Society of Basic and Applied Physiology, 2022) Ayinde, T.O.,; Olohungbebe, K.A., .; Ojulari, L.S.,; Sanni, M.A.,; Oluwasola, A.,; Afodun, A.M.,; Balogun, M.EBackground: Occupational hazards are specific dangers workers are exposed to, at work environments, due to tools, or interactions among co-workers. This is also seen among local bakers exposed to undue heat culminating into several unreported health conditions making the victims to indiscriminately and erroneously take blood supplements as antidotes. This study was conducted to explore the effect of prolonged environmental heat exposure on red blood cells indices in vivo among local bakers in Ilorin metropolitan city. Methodology: One hundred office workers and 100 local bread bakers with 5 years and above working exposure to prolonged heat were selected from 10 different local bakeries in Ilorin. Following completion of a questionnaire, blood samples were collected for assessment of red blood cell indices. Result: There was significant (p<0.05) increase in levels of haemoglobin, packed cell volume, and mean corpuscular haemoglobin, while there was no significant (p>0.05) change in the levels of RBC, MCV and MCHC, though there was increase. Conclusion: In conclusion, the result of this study demonstrated that prolonged heat exposure caused increase in the level of haemoglobin, packed cell volume, and mean corpuscular haemoglobin. However, red blood cell count, mean corpuscular volume, and mean corpuscular haemoglobin concentration of the bakery workers were uneventful compared to that of the control.Item Effects of Melatonin on Estrous Cycle Changes Induced by Ethanolic Extract of Cannabis-sativa in Female Wistar Rats.(Society for Experimental Biology of Nigeria, 2019) Oluwasola, A.,; Olayaki, L.A.; Ayinde, T.O.This study investigated the effects of melatonin and ethanolic extract of Cannabis-sativa (EECS) on oestrus cycle and reproductive hormones in reproduction of female rats. Twenty female rats were assigned into four groups of five animals each, such that the rats in groups I, II, III and IV received orally 1mL distilled water, 2mg/kg body weight (BW) of EECS, 2mg/kg BW of EECS plus 4mg/kg BW of melatonin and 4mg/kg BW of melatonin, respectively. Vaginal smear was taken daily to determine the Stages of oestrus cycle using light microscope (x400) between 8am-9am. Gonadotropin releasing hormone (GnRH), Luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol (E), progesterone and prolactin were also determined using standard methods. EECS significantly (p<0.05) lengthened the metestrus and diestrus phases of oestrus cycle. However, it significantly (p<0.05) shortened the proestrus and estrus phases. CS significantly (p<0.05) decreased GnRH, FSH, LH, E, progesterone and prolactin levels respectively. All these effects were ameliorated when combined with melatonin to the level comparable to the control. This study showed the gonadotoxic effects of EECS which could be mediated by endocrine disruption. However, these effects could be ameliorated by melatonin. Since the consumption of CS is increasing globally because of its medical uses leading to its legalization, therefore, consumption of melatonin as supplement is recommended for its users to prevent its gonadotoxic effects.Item Ethanolic Extract of Nauclea latifolia (African Peach) Protects Against Ethanol-Induced Gastric Mucosal Injury in Rats.(Faculty of Health Sciences, Al-Hikmah University, 2021) Balogun, M.E.,; Ayinde, T.O.,; Oluwasola, A.,; Busari, A.O.,; Ajibola, K.A.; Abubakar, M.MNauclea latifolia is widely used in folk medicine in Nigeria and some West African countries. In vivo study was conducted to investigate the gastroprotective effects of ethanolic leaf extract of N. latifolia (EENL) on ethanol-induced gastric ulcerated rats. Methods: Gastric mucosal ulceration was induced experimentally in Groups 2 to 5 rats using ethanol. Five groups of rats were orally pretreated with 3% Tween-80 only as vehicle group, 3% Tween-80 as ulcer group, 20 mg/kg of omeprazole as positive group, 250 and 500 mg/kg of EENL as the test groups, respectively before ulcer induction. Gastric secretion parameters and ulcerated areas were assessed. Results: Pretreatment with EENL showed significant (P < 0.05) reduction in gastric volume and ulcer index while the pH of gastric content increased significantly (P < 0.05) in rats with ethanol-induced ulcer. Ulcer group exhibited significantly severe mucosal injury and EENL or omeprazole offered significant (P < 0.05) protection against gastric mucosal ulceration. Conclusion: The study suggests that EENL has a protective action against gastric ulcers induced by ethanol in Wistar rats. The protective effect might be mediated via antisecretory and cytoprotective mechanisms.Item Hepatoprotective Effect of Tryptophan in Carbontetrachloride-Induced Hepatotoxicity in Male Wistar Rats.(Society of Basic and Applied Physiology, 2021) Ayinde, T.O.,; Olayaki, L.A.,; Ojulari, L.S.,; Oluwasola, A.,; Abdulraheem, H.A.,; Lawal, A.Z.,; Alli-Oluwafuyi, A.In the present study, tryptophan was evaluated for its hepatoprotective effects against carbontetrachloride-induced hepatocellular injury in rats. Hepatotoxicity was induced in male SpragueDawley rats by intraperitoneal injection of CCl4 (4ml/kg) in olive oil (1:1). Tryptophan at doses of 100mg/kg and 200mg/kg was administered orally for 28 days. The hepatoprotective effect of tryptophan was evaluated by the assay of biochemical parameters viz.: alanine aminotransaminase (ALT), aspartate aminotransaminase (AST), alkaline phosphatase (ALP), total protein, albumin and lipid peroxidation. Tryptophan produced a dose-dependent significant increase (p<0.001) in serum ALP (41% & 60%), a dose-dependent decrease (p<0.001) in serum Malondialdehyde (61% & 65%), and a significant increase (p<0.001) in levels of serum protein and serum albumin, in CCl4induced hepatotoxic rats, following administration of 100 mg/kg bwand 200 mg/kg bw, respectively. The toxic effect of CCl4 in tryptophan treated groups was controlled significantly by restoration of the levels of enzymes, total protein and albumin as compared to the CCl4 treated groups. The results suggest that tryptophan is able to significantly alleviate the hepatotoxicity induced by CCl4 and may be attributed to the antioxidant property of tryptophan.Item Nauclea Latifolia (African Peach) Attenuates Gastric Acid Secretion in Rats with Ethanol-Induced Ulceration(Faculty of Health Sciences, Al-Hikmah University, 2021) Balogun, M.E.,; Umahi, G.O.,; Ayinde, T.O.,; Oluwasola, A.,; Busari, A.O.,; Ajibola, K.A.,; Yusuf, R.O.; Ojulari, L.S