Browsing by Author "Olutoyin C. Adekunle"

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    Phytochemical Analyses, Antimicrobial Activities and Possible Antimicrobial Mechanism of Adansonia Digitata: An Animal Model
    (Alexandria Journal of Veterinary Sciences, 2022-07-01) Olutoyin C. Adekunle; Temitope I. Adelusi; Ismaila O. Sule; Akanmidu R. Olorunfemi; Abdulrahim Halimat A.; Adeniran S. Adekunle
    The advent of antibiotics recorded a huge amount of success against disease- causing microbes. However, development of resistance to reference antibiotics leading to increased mortality have caused critical concern in the management of infectious diseases. Continuous search for alternative therapies has shown good candidates in medicinal plants, although without thorough examination of possible mechanism of action. This study assessed the phytochemical constituents, antimicrobial activities, and possible antimicrobial mechanism of Adansonia digitata, against Shigella flexneri, Escerichia Coli and Salmonella enteritis. Phytochemical analyses showed that Adansonia digitata is rich phytosterols, flavonoids, phenolics and carotenoids. Assessments of antimicrobial activities of A. digitata revealed its effectiveness against S. flexneri, E. coli and S. enteritis. The mechanism of antimicrobial activities of A. digitata may involve inhibition of Gram+ and Gram- transpeptidase and dihydrofolate reductase. The antimicrobial activities may be ascribed to the presence of phytochemicals in A. digitata.