Browsing by Author "Olorundare, O.E.,"

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    Iloneoside: a cytotoxic ditigloylated pregnane glycoside from the leaves of Gongronema latifolium Benth.
    (Taylor & Francis., 2018) Gyebi, G.A.,; Adebayo, J.O.,; Olorundare, O.E.,; Pardede, A.,; Ninomiya, M.,; Afolabi, O. S.,; Babatunde, A.S.,; Koketsu, M.
    Gongronema latifolium Benth (Asclepiadaceae) is an edible-green-leafy vegetable with known medicinal value. A chemical investigation of the 80% methanolic extract of the leaves led to the isolation of a new pregnane glycoside: iloneoside (3-O-[6-deoxy-3-O-methyl-β-D-allopyranosyl-(1→14)-β-D-oleandropyranosyl]-11,12-di-O-tigloyl-17β-marsdenin), together with four known constituents. Their chemical structures were determined by spectroscopic analysis. The isolates were tested for their in vitro growth inhibitory activity against human leukemia HL-60 cells. Iloneoside was the most active and gave apoptotic response. Molecular docking analysis demonstrated that iloneoside could be accommodated within hot spots of anti-apoptotic protein Bcl-2. These results suggest G. latifolium as a reliable source of potent anticancer compounds.
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    Sub-Acute Toxicological Evaluation of An Artemisia-Based Moringa Supplement (AMS)
    (Published by the College of Health Sciences, University of Ilorin, 2025) Afolabi, Saheed O.; Olorundare, O.E.,; Akanbi, O.B.,; Bello, M.K.; Folahan, J.T; Ibiyemi, S
    Background: In developing nations, several natural medicine practitioners explore the use of plant-based supplements and other forms of phytotherapies to combat viral infection via immune-boosting mechanisms. One such supplement is a locally compounded and consumed Moringa supplement containing and named, artemisia-based Moringa supplement (AMS). The aim of this study was to evaluate the effect of a subacute (30 days) administration of AMS on the toxicological indices in albino Wistar rats of both sexes. artemisia annua Results: There were no adverse hematological effects because of AMS treatment. Serum electrolytes levels were not affected across the doses of AMS administered for 30 days. Creatinine levels were not significantly altered, however a significant (p = 0.037) reduction in urea level was observed in the highest dose of 500 mg/kg. Liver function assays showed no significant alterations in the liver function enzymes, although, a significant decrease in the liver malonaldehyde (MDA, product of lipid peroxidation) level was observed. There was no adverse effect on kidney function parameters and serum lipid profile.