Browsing by Author "Olorundare, O.E."
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Item Acute and Sub-acute Toxicities of Defatted Ethanolic Extract of Moringa Oleifera seed in Albino Rats(West African Society for Pharmacology, 2015) Olorundare, O.E.; Bello, M.K.; Biliaminu, S.A.; Babatunde, A.S.; Ibrahim, O.O.K.; Anoka, A.A.Item Antidiabetic and antihyperlipidemic effects of aqueous extract of Parquetina nigrescens in streptozotocin–nicotinamide induced type 2 diabetic rats.(Elsevier Group, Netherlands, 2021) Ojuade, F.I.; Olorundare, O.E.; Akanbi, O.B.; Afolabi, S.O.; Njan, A.A.Background Parquetina nigrescens is among the evergreen plants native to West Africa. It is used in the management of various ailments including anemia, fever, asthma and diabetes. This study evaluated the antidiabetic and antihyperlipidemic effect of Parquetina nigrescens in streptozotocin–nicotinamide-induced type 2 diabetic rats. Methods Type 2 diabetes mellitus was induced in overnight fasted rats with a single intraperitoneal injection of streptozotocin (60 mg/kg), followed by the administration of nicotinamide (120 mg/kg) after an interval of 15 min. Diabetic rats were orally administered with; 200, 400 and 800 mg/kg of aqueous extract of Parquetina nigrescens (AEPN), metformin (180 mg/kg) and glibenclamide (1 mg/kg) for two weeks. The effect of treatments on fasting blood glucose, serum insulin, leptin, adiponectin, homa-ir, lipid profile, body weight, pancreatic antioxidants parameters, hepatic glycogen content, glucose-6-phosphate activity, α-amylase inhibition, α-glucosidase inhibition, lipase inhibition and histology of the organs were evaluated. Results Data from this study showed that treatment with AEPN produced a significant reduction (p < 0.05) in fasting blood glucose, glucose-6-phosphatase activity, serum lipase, total triglyceride, total cholesterol, low-density lipoproteins, very low-density lipoprotein, atherogenic index, coronary risk index, pancreatic α-amylase, α-glucosidase and lipase activities. Treatment with AEPN also produced a significant (p < 0.05) increase in; glucose tolerance, glycogen content, leptin, adiponectin and pancreatic antioxidants (glutathione, superoxide dismutase, catalase and high-density lipoproteins). The histology of the organ showed regeneration of the pancreatic tissue after treatment with AEPN. Conclusions This study showed that AEPN exhibited antidiabetic and antihyperlipidemic activity in streptozotocin–nicotinamide-induced type 2 diabetic rats.Item Antisecretory and Spasmolytic potential of Ethanolic leaf extract of Datura stramonium Linn in Albino Wistar Rat and Guinea pig ileum models(2016) Afolabi, S.O.; Alli-Oluwafuyi, A.M.; Olorundare, O.E.; Olaleye, S.; Adeyemi, O.O.; Odukanmi, O.Item Apoptotic Potential of Iloneoside from Gongronema latifolium Benth against Prostate Cancer Cells Using In Vitro and In Silico Approach(2024) Gyebi, G.A.; Afolabi, S.O.; Ogunyemi, O.M.; Ibrahim, I.M.; Olorundare, O.E.; Adebayo, J.O.; Koketsu, MItem Screening of Selected Nigerian Medicinal Plants/Seeds for Growth Inhibitory Activity against Human Leukemia HL-60 Cells and DPPH Radical Scavenging Activity(2021) Afolabi, Saheed O.; Gyebi, G.; Agede, O.; Njan, A.; Olorundare, O.E.