Browsing by Author "Olokoba, Abdulfatai Bamidele"

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    A clinicopathological review of colonic polyps in a tertiary Hospital in North Central Nigeria
    (Faculty of Medicine, Omdurman Islamic University, 2018) Bojuwoye, Matthew Olumuyiwa; Olokoba, Abdulfatai Bamidele; Ogunmodede, James Ayodele; Agodirin, Sulaiman Olayide; Ibrahim, Olatunde O. Kazeem; Adeyeye, Ademola A; Bamidele, Opeyemi F; Ogunlaja, Olumuyiwa Ayotunde; Okonkwo, Kenechukwu C; Aliyu, Aminu Mansa
    Background: Colorectal polyps, especially adenomas, are known as precursors of colorectal carcinomas. This study was aimed at determining the prevalence and histopathologic characteristics of colonic polyps among Nigerians that underwent colonoscopy at the University of Ilorin Teaching Hospital, Ilorin, Nigeria. The authors also determined the polyp detection rate and adenoma detection rate. Materials and Methods: This was a hospital-based cross-sectional study of all colonoscopy examinations performed at the University of Ilorin Teaching Hospital, Ilorin from March2013 to September2017. The endoscopy register was reviewed, and patients’ biodata, indications for colonoscopy and colonoscopic findings were recorded on a proforma. The histopathologic reports of the polyps were also retrieved and their diagnosis confirmed. Results: A total of 289 patients had colonoscopy carried out on them. The age of the patients ranged from 14 to 90 years with a mean ± SD of 57.0 ± 15.3 years and a median age of 58years. There were 178(61.6%) males and 111 (38.4%) females giving a M:F ratio of 1.6:1. The indications for colonoscopy were rectal bleeding124(42.9%); suspected colorectal cancer 67(23.2%); abdominal pain 22 (7.6%); chronic diarrhea 18 (6.2%); surveillance colonoscopy 12 (4.2%); constipation 11(3.8%); change in bowel habit 9(3.1%); occult bleeding 6(2.1%); others 20(6.9%). Endoscopic findings were normal findings 89(30.8%); hemorrhoids 88 (30.4%); colonic polyps 50 (17.3%); diverticulosis 34 (11.8%); rectal cancer 29 (10.0%); colon cancer 24 (8.3%); colitis 19 (6.6%); others 13 (4.5%). The findings were not mutually exclusive. The diagnostic yield was 69.2%. The overall polyp detection rate was 17.3%. Of the 50 patients with polyps, 33 (66.0%)were males (p=0.481). The adenoma detection rate was 4.8%. Conclusion: The authors conclude that their observed polyp detection rate is consistent with the estimated rates for Africa. Rectal bleeding and adenomatous polyps were the commonest presentation and histopathologic finding, respectively
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    A STUDY OF THE CLINICAL PROFILE OF PATIENTS WITH HEPATOCELLULAR CARCINOMA IN ILORIN
    (The Society for Gastroenterology and Hepatology in Nigeria (SOGHIN), 2020) Olokoba, Abdulfatai Bamidele; Bojuwoye, Matthew Olumuyiwa; Ogunmodede, James Ayodele; Bamidele, Opeyemi F; Okonkwo, K.C.; Aliyu, Aminu Mansa; Ogbu, Lawrence O.
    Background: Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and the sixth most common cancer worldwide. Despite being the 6th most common cancer it is the second leading cause of cancer related deaths. It is a major cause of cause of morbidity and mortality in Nigeria. Aim: To study the symptom profile and the prevalence of hepatitis B and C viral infection among patients with HCC in University of Ilorin Teaching Hospital (UITH), Ilorin. Methodology: This was a cross-sectional study of patients with HCC managed at the study center from January 2013 to December 2017. The diagnosis of HCC was made based on the symptoms, physical examination and radiological findings. A structured proforma was used to obtain socio-demographic, clinical presentation and laboratory data from patients who met our inclusion criteria. The data obtained was analyzed using the statistical package for social sciences version 22. Results: A total of 109 HCC patients whose ages ranged from 23-89 years with a mean age (SD) of 45.3 (14.0) years were studied. Eighty-two (75.2%) of these were males and the < 45 years age group had the highest frequency of 57 (52.3%). Weight loss 100 (91.7%), abdominal swelling 98 (89.9%) and abdominal pain 96 (88.1%) were the most prevalent presenting complaints. Jaundice 47 (43.1%), wasting of the small muscles of the hand 35 (32.1%), sparse axillary hair 25 (22.9%) and finger clubbing 24 (22.0%) were the prevailing stigmata of chronic liver disease whereas liver tenderness 85 (75.2%), irregular liver surface 79 (72.5%), hard liver 64 (58.7%) and ascites 65 (59.6%) were the commonest findings on abdominal examination. These were not mutually exclusive. The prevalence of hepatitis B and C among the patients with HCC was 56.9% and 3.7% respectively. Conclusion: HCC is more prevalent among young persons aged < 45 years and among males in UITH, Ilorin. Weight loss, abdominal pain and swelling are the commonest presentation. The prevalence of hepatitis B infection among them is high whereas that of hepatitis C is low.
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    Colonoscopic examination of rectal bleeding in children: A report of two cases.
    (The Association of Paediatric Surgeons of Nigeria and the Pan-African Paediatric Surgical Association, 2012) Olokoba, Abdulfatai Bamidele; Obateru, Olusegun A; Bojuwoye, Matthew Olumuyiwa; Ibrahim, O.O.K.; Babalola, O.M
    Rectal bleeding in children is a frightening and cause of great concern, and of parental anxiety. In this report, we present the value of colonoscopy to unravel the diagnostic conundrum often associated with rectal bleeding in children.
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    Familial adenomatous polyposis syndrome with colorectal cancer in two Nigerians: a report of two cases and review of literature
    (African field epidemiology network (AFENET), 2018) Bojuwoye, Matthew Olumuyiwa; Olokoba, Abdulfatai Bamidele; Ogunlaja, Olumuyiwa Ayotunde; Agodirin, Sulaiman Olayide; Ibrahim, Olatunde O. Kazeem; Okonkwo, Kenechukwu C; Aliyu, Aminu Mansa
    Familial adenomatous polyposis syndrome is a rare condition characterized by the presence of numerous adenomatous polyps in the gastrointestinal tract and associated with risk for colorectal cancer. The disease is scarcely reported in Nigeria and this is the index report in Ilorin. Two cases were clinically diagnosed in our facility. They both presented with gastrointestinal bleeding and numerous rectal and colonic polyps were identified at colonoscopy. Histological examination of the polyps in both cases revealed features in keeping with adenomatous polyps. This report highlights the occurrence of this precancerous condition.
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    Helicobacter pylori eradication therapy: A review of current trends
    (Nigerian Medical Association, 2013-01) Olokoba, Abdulfatai Bamidele; Obateru, Olusegun A; Bojuwoye, Matthew Olumuyiwa
    Helicobacter pylori has been implicated in the formation of chronic gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue lymphoma and gastric cancer. Eradication of H. Pylori has been recommended as treatment and prevention for these complications. This review is based on a search of Medline, the Cochrane Database of Systemic Reviews, and citation lists of relevant publications. Subject heading and key words used include H. Pylori, current treatment and emerging therapy. Only articles in English were included. There has been a substantial decline in the H. pylori eradication rates over the years, despite the use of proton pump inhibitor and bismuth salts for triple and quadruple therapies respectively. The reasons for eradication failure are diverse, among them, antibiotic resistance is an important factor in the treatment failure. Primary resistance to clarithromycin or metronidazole significantly affects the efficacy of eradication therapy. This has led to the introduction of second line, third line “rescue,” and sequential therapies for resistant cases. Subsequently, new antibiotic combinations with proton-pump inhibitors and bismuth salts are being studied in the last decade, to find out the antibiotics that are capable of increasing the eradication rates. Some of these antibiotics include Levofloxacin, Doxycycline, Rifaximin, Rifampicin, Furazolidone based therapies. Studies are ongoing to determine the efficacy of Lactoferrin based therapy.
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    Hepatocellular Carcinoma - A Synopsis Of Current Developments
    (College of Health Sciences, University of Ilorin, Ilorin, 2017-10) Olokoba, Abdulfatai Bamidele; Obateru, Olusegun A; Bojuwoye, Matthew Olumuyiwa; Olokoba, Lateefat B.
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    Indications and findings at colonoscopy in Ilorin, Nigeria
    (Nigerian Medical Association, 2013) Olokoba, Abdulfatai Bamidele; Obateru, Olusegun A; Bojuwoye, Matthew Olumuyiwa; Olatoke, Samuel Adegboyega; Bolarinwa, Oladimeji Akeem; Olokoba, Lateefat Bukola
    Background: Colonoscopy is a safe and effective means of visual inspection of the large bowel from the distal rectum to the caecum. It may be carried out for diagnostic and or therapeutic reasons. There is a paucity of data on this procedure in Nigeria. We, therefore, determined the indications, findings, and diagnostic yield in Nigerians at colonoscopy. Materials and Methods: This was a hospital-based cross-sectional study carried out at the Endoscopy unit of Crescent hospital, Ilorin from January 2010 to May, 2012. The endoscopy register was reviewed, and the biodata, indications and colonoscopic findings were recorded on a pro forma. Results: A total of 103 patients had colonoscopy. Seventy (68.0%) were males while 33 (32.0%) were females. The indications for colonoscopy were rectal bleeding 41 (39.8%), suspected colon cancer 32 (31.1%), chronic constipation and chronic diarrhoea nine each (8.7%), abdominal/anal pain five (4.9%), suspected anorectal cancer and enterocutaneous fistula two each (1.9%), faecal incontinence, occult gastrointestinal bleeding, post-colostomy for Hirschsprung disease one each (1.0%). Endoscopic findings were normal findings 21 (20.4%), diverticulosis 17 (16.5%), polyps 16 (15.5%), haemorrhoids 16 (15.5%), anorectal cancer 13 (12.6%), angiodysplasia 12 (11.7%), colon cancer eight (7.8%), colitis 7 (6.8%), anorectal ulcer 4 (3.9%), anal warts two (1.9%), anal fissure, caecal tumour, faecal impaction and proctitis one each (1.0%). The diagnostic yield was 79.6%. Conclusions: The commonest indication for colonoscopy was rectal bleeding, while the most frequent pathology was diverticulosis. The diagnostic yield was high.
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    Lower gastro-intestinal tract bleeding in Ilorin, Nigeria
    (The Egyptian Society of Surgeons, Egypt, 2013-10) Olokoba, Abdulfatai Bamidele; Bojuwoye, Matthew Olumuyiwa; Obateru, Olusegun A.
    Introduction: Lower gastro-intestinal bleeding refers to blood loss of recent onset originating from a site distal to the ligament of Treitz. It may manifest as haematochezia (passage of maroon or bright red blood or blood clots per rectum). Information is scanty on the subject in Nigerians. Aims and Objectives: To determine the colonoscopic findings in Nigerians with lower gastro-intestinal bleeding in Ilorin. Methodology: This was a hospital-based cross-sectional study carried out at the Endoscopy suite of Crescent hospital, Ilorin from January 2010 to April, 2013. The endoscopy register was reviewed, and the biodata, indications and colonoscopic findings were recorded on a proforma. Results: A total of 174 patients had colonoscopy carried out on them. Out of these, seventy eight had lower gastro-intestinal bleeding comprising 52 (66.7%) males and 26(33.3%) females. Their age ranged from 4 to 90 years with a mean of 53.3+/-19.9 years. The colonoscopic findings were haemorrhoids 28(35.9%); diverticulosis 20(25.6%); rectal cancer 13(16.7%); colonic polyps 12(15.4%); angiodysplasia 9(11.5%); proctitis 4(5.1%); rectal polyps 4(5.1%); anal warts 3(3.8%); anal cancer 2(2.6%); colitis 2 (2.6%); colon cancer 1(1.3%); normal findings 4 (5.1%). Conclusions: Haemorrhoids, diverticulosis, colo-rectal cancer, and polyps in decreasing order are the commonest findings in Nigerians with lower gastro-intestinal bleeding.
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    Oesophageal intramural pseudodiverticulosis: a rare endoscopic finding
    (Ghana Medical Association, 2019) Bamidele, Opeyemi F; Olokoba, Abdulfatai Bamidele; Bojuwoye, Matthew Olumuyiwa; Barde, Amanda A
    Oesophageal intramural pseudodiverticulosis is an uncommon condition, characterized by multiple small rounded cavities seen in the oesophageal wall during oesophagogastroduodenoscopy. It is often associated with gastro-oesophageal reflux disease, achalasia, oesophageal candidiasis and diabetes mellitus. We report a 40 year old Nigerian man who presented with recurrent dysphagia and endoscopic findings typical of oesophageal intramural pseudodiverticulosis. The patient was managed medically with resolution of the dysphagia. This report highlights the occurrence of this rare and benign cause of dysphagia in Nigeria.
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    Prevalence of minimal hepatic encephalopathy among patients with chronic liver disease in Ilorin, Nigeria
    (Ghana Medical Association, 2019) Bamidele, Opeyemi F; Olokoba, Abdulfatai Bamidele; Bojuwoye, Matthew Olumuyiwa; Akintayo, Richard O; Bamidele, Oluwakemi
    Background: Minimal Hepatic encephalopathy is the mildest form of Hepatic Encephalopathy which presents with significant cognitive impairment and affectation of activities of daily living. The literature is scanty on the prevalence of minimal hepatic encephalopathy in Nigerians with chronic liver disease. Aim: This study aimed at determining the prevalence of minimal hepatic encephalopathy among patients with chronic liver disease using neuro-psychometric tests. Methods: The study was a hospital-based cross-sectional study carried out at the University of Ilorin Teaching Hospital, Ilorin from February 2015 to February 2016. Chronic liver disease was diagnosed with the presence of peripheral stigmata of liver disease, liver biochemistry, prothrombin time, and sonographic findings in keeping with liver disease. Minimal hepatic encephalopathy was diagnosed using number connection tests-A and B for patients who were educated while Line tracing test and constructional dyspraxia were used for patients without any formal education. Data obtained were analysed using Statistical Package for the Social Sciences (SPSS) version 20 computer software package. Results: Sixty-four patients with chronic liver disease were recruited. The mean age (SD) of the patients was 47.1±14.6 yrs, and the 30-39 and 40-49 yrs age groups each had the highest frequency of 21(32.8%). There were 54 (84.4%) males and 10 (15.6%) females. The prevalence of Minimal Hepatic Encephalopathy was 43.8%. Conclusion: The prevalence of Minimal Hepatic Encephalopathy in this study was similar to previous studies. Significant number of patients with minimal HE were in Child-Pugh class B and C.
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    Self-reported symptoms of uninvestigated dypepsia among University staff in Ilorin, Nigeria
    (College of Health Sciences, Osun State University, 2016) Bojuwoye, Matthew Olumuyiwa; Ogunmodede, James Ayodele; Olokoba, Abdulfatai Bamidele; Bolarinwa, Oladimeji Akeem; Kolo, Philip Manma
    Objectives: Dyspepsia is a common gastrointestinal (GI) symptom which impacts negatively on quality of life, workplace efficiency and overall productivity. Many studies on dyspepsia in our environment are hospital based, but being a complaint frequently treated first by self-medication before presentation to the hospital, such studies may underestimate its prevalence. The objective of the study was to determine the prevalence of the dyspepsia and its associated factors among administrative staff of the College of Health Sciences, University of Ilorin, Nigeria. Methods: This was a cross-sectional study. Pretested structured, close-ended, interviewer-administered questionnaires were administered to 53 administrative staff selected across the different units by stratified random sampling. The questionnaire obtained information about subject's experiences of dyspeptic symptoms and presence of associated factors such as family history, non-steroidal anti-inflammatory drugs (NSAIDS), tobacco and alcohol use, and presence of diabetes mellitus (DM). Results: The prevalence of uninvestigated dyspepsia among the respondents was 37.5%. Age was significantly predictive of the occurrence of dyspepsia among the subjects Odds Ratio- 1.46, 95% Confidence Interval (1.042-2.045) P=0.03. Use of NSAIDS, presence of DM, family history and tobacco use were not predictive of occurrence of dyspepsia
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    Spectrum of oesophagogastroduodenoscopy findings in patients presenting with upper gastrointestinal bleeding in a tertiary hospital in Ilorin
    (The Society for Gastroenterology and Hepatology in Nigeria (SOGHIN), 2023) Bojuwoye, Matthew Olumuyiwa; Obateru, Olusegun Ayodeji; Aliyu, Aminu Mansa; Okonkwo, Kenechukwu Chukwuemeka; Ogbu, Lawrence Ogbonnaya; Ojimi, Olajumoke Olubusayo; Arinde Olufemi; Safiu, Kamorudeen Ishola; Olokoba, Abdulfatai Bamidele
    Background: Upper gastrointestinal bleeding (UGIB) is a common and potentially life-threatening condition. Oesophagogastroduodenoscopy (OGD) is an invaluable tool in the investigation and management of UGIB. Aim: We studied the spectrum of endoscopy findings among patients who were referred for OGD on account of UGIB. Methodology: This was a cross-sectional study of patients who had OGD done at the University of Ilorin Teaching Hospital on account of UGIB from year 2010 to 2022. Endoscopies were performed as per the standard protocol with diagnosis based on accepted criteria. Data were retrieved from the endoscopy register, entered into a spreadsheet, and analyzed using the Statistical Package for Social Sciences (SPSS) version 22. Categorical variables were compared using a Chi-square test and statistical significance set at P < 0.05. Results: A total of 1438 patients (mean age: 51.0 ± 16.4 years; age range, 10–100 years; 730 [50.8%] females) were included. Of these patients, 280 (19.5%) presented with UGIB. Peptic ulcers disease (PUD) 68 (24.3%) followed by gastritis 50 (17.9%), esophageal/gastric varices 42 (15.0%), gastroduodenitis 20 (7.1%) and gastric tumors 18 (6.4%) were the commonest causes of UGIB in the study population. Of the 68 cases of PUD, 43 were duodenal ulcers whereas 25 were gastric ulcers. The mean age of patients with UGIB was 51.0 ± 20.0 years and it was more common in males 187 (66.8%); P < 0.05. Conclusion: UGIB was more common in males and the most common cause of UGIB in our study population was PUD
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    That dyspepsia in the young could be cancer
    (Nigerian Medical Association, 2013) Olokoba, Abdulfatai Bamidele; Obateru, Olusegun A; Bojuwoye, Matthew Olumuyiwa; Ibrahim, Olatunde Kazeem; Olokoba, Lateefat Bukola
    Malignant tumour of the stomach is not common in young adults. When it does occur, it is associated with a high morbidity and mortality. The objective of this report is to document our experience with three cases of gastric adenocarcinoma in young adult Nigerians seen over a period of 18 months in our centre.
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    The Indications and Findings at Colonoscopy in a Tertiary Hospital in North-Central Nigeria: A Seven-Year Review
    (West African College of Physicians, 2021) Bojuwoye, Matthew Olumuyiwa; Bamidele, Opeyemi F; Okonkwo, K; Adeyeye, Ademola A; Aliyu, Aminu Mansa; Oyeleke, Ganiyat Kikelomo; Olokoba, Abdulfatai Bamidele
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    The Indirect Victims of COVID-19: Perception of Non-COVID-19 Patients about the Effect of Closure of the Medical Outpatient Services on their Health
    (West African College of Physicians, 2022-04) Ogunmodede, James Ayodele; Bolarinwa, Oladimeji Akeem; Ogunmodede, Adebusola Jane; Bojuwoye, Matthew Olumuyiwa; Bello, Abiodun Hamza; Dele-Ojo, Bolade F; Yusuf, I.A.; Abiola, T.S.; Olokoba, Abdulfatai Bamidele; Kolo, Philip Manma
    Background: In order to reduce COVID-19 transmission and protect healthcare workers, the outpatient departments (OPDs) in many hospitals worldwide were closed down in the early days of the pandemic. Patients being managed for chronic medical illnesses who subsequently suffered reduced access to healthcare have been described as “the patients left behind”. Aim: The study aimed at assessing the impact of the closure of the Medical OPD in University of Ilorin Teaching Hospital (UITH) on the health and perceived well-being of patients with chronic medical illnesses. Methods: A cross-sectional study of 180 patients with chronic medical illnesses attending the MOPD in UITH. Results: Mean age of participants was 50.2±18.2years, 92 (51.1%) were male, median duration of attending MOPD was 21 months (IQR 12-36). 92 patients (51.1%) perceived a negative affectation of their well-being by the closure of MOPD. Being >50 years was associated with a perception of negative affectation of well-being (P=0.042). 140 patients (77.8%) had clinic appointments that fell within the period under review. 67(69.3%) of the 97 patients who had medical complaints during the period could not reach a doctor and this was associated with a perception of negative affectation of their wellbeing. The commonest action they took was to do nothing (28.3%), three (4.5%) resorted to herbal concoctions. 19 (29.9%) felt their complaints were urgent. Conclusion: Our study identifies that patients with chronic medical illness are potential victims of COVID-19 related disruption of healthcare services. Healthcare managers in Nigeria must develop alternatives such as telemedicine that sustain face-to-face medical interaction during eventualities
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    The knowledge and attitude of students of a Nigerian tertiary institution about peptic ulcer disease
    (College of Health Sciences, Osun State University, Osun State, 2021) Bojuwoye, Matthew Olumuyiwa; Ogunmodede, James Ayodele; Ogunlaja, Olumuyiwa Ayotunde; Fasiku, Mojirola Martina; Oyeleke, Ganiyat Kikelomo; Olokoba, Abdulfatai Bamidele
    Objectives: This study was aimed at assessing the knowledge and attitude of students of a tertiary institution in North-Central Nigeria about peptic ulcer disease (PUD) Methodology: Three hundred students of the Kwara State Polytechnic, Ilorin, were recruited using a multistage sampling method. A semi-structured questionnaire was used to obtain socio-demographic data and assess their knowledge about and attitude towards PUD. Results: Two hundred and thirty-four (78.0%) of respondents had heard about PUD before. Two hundred and fifty (83.3%) of the respondents thought PUD was a gastrointestinal disease whereas 40 (13.3%) thought it was a disease of the heart. Only one (0.3%) of the respondents knew Helicobacter pylori as a cause of PUD, and only 17.3% believed drugs could treat PUD. Students of Science-based courses were twice as likely as non-Science based students to have had a prior knowledge of PUD (OR: 1.98, CI: 1.054 3.717, P=0.034). Conclusion: Though majority of respondents had heard about PUD, their knowledge of its aetiology, symptoms and treatment was poor. This reflects the need to strengthen public health education about PUD because of its potential for causing morbidity and mortality