Browsing by Author "Olayaki L.A."

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    Alterations in the levels of female sex hormones following administration of nicotine to Wistar rats
    (Library and Publications Committee, University of Ilorin, 2019) Omotoso G.O.; Kadir R.E.; Alabi A.S.; Olayaki L.A.; Femi-Akinlosotu O.
    The indiscriminate use of nicotine is a serious public health challenge worldwide. In this work, the effect of nicotine was studied on female sex hormones using adult female Wistar rats. Fifteen (15) animals were grouped into three equally as, Group A (Control, given 0.1 ml of normal saline), Group B (given 0.03 mg/kg nicotine), and Group C (received 0.06 mg/kg nicotine). All administration was via the intraperitoneal route, once daily for five (5) consecutive days. All the animals were sacrificed by cervical dislocation about 24 hours after the last treatment, and intracardial blood samples obtained. Using appropriate biochemical kits, the serum levels of follicle-stimulating hormone (FSH), luteinising hormone (LH), prolactin, oestrogen and progesterone were determined. The results showed a dose-dependent significant increase in serum levels of the gonadotropins and progesterone, and a marked increase in serum levels of oestrogen and prolactin in animals treated with low dose nicotine, but significantly low levels of these hormones were recorded in animals treated with higher dose of nicotine. Administration of nicotine affects the female sex hormones adversely, and this by extension could affect female reproductive activities.
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    Morphology and Histoarchitectural of the Cerebellum of Grasscutter (Thyronomys swinderianus) and Hedgehog (Atelerix albiventris)
    (Centre Point Journal (Science Edition). The official Journal of Library and Publications Committee, University of Ilorin, Ilorin, 2016) Ajao M.S.; Usman I.T.; Abioye A.I.R.; Imam A.; Olawepo A.; Adana M.Y.; Kareem S.B.; Olayaki L.A.
    The study investigated the general morphology and histoarchitecture of the cerebellar of grasscutter and the Hedgehog. Six grasscuttters and six hedgehogs were used for the study. They were obtained from Jobavic farm in Ilorin, Nigeria. The animals were euthanised, transcardially perfused with 0.9% normal saline and by 4% paraformaldehyde solution. the brains of the animals were removed and the cerebellum detached, weighed and processed for histological purpose and comparism. the findings of this study show a well organised gyration and sulci in the grasscutter compared to the hedgehog. the brain and cerebellar weights of the grasscutter are comparably larger than that of the hedgehog. However the cerebellar cortices and the histoarchitecture of the two animals were similar with little variations in the cellular layers especially the Purkinje cell layer. The study concludes that that though there are no marked histological differences between the cerebellar cortices in the two animals, the observed complex motor functions in the grasscutter may be explained by the complexities in their cerebellar gyration and sulci.