Browsing by Author "Olawumi, Hannah"

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    Fibrinolytic proteins of normal pregnancy and pre-eclamptic patients in North West Nigeria
    (2018) Oladosu-Olayiwola, Rashidat Oluwatosin; Olawumi, Hannah; Babatunde, Abiola; Ijaiya, Munirdeen; Durotoye, Idayat; Biliaminu, Sikiru A; Ibraheem, Rasheedat M
    Background: The hypercoagulability of pregnancy is exaggerated in pre-eclamptic state because of endothelial activation with resultant production of some endothelial derived proteins that are said to be inhibitors of fibrinolysis. This study compares these proteins like tPA, PAI-1 and D-dimers in normal pregnant women and the pre-eclamptic women. Methodology: This was a comparative cross-sectional study. Eighty-five pre-eclamptic women were recruited as subjects and eighty five age, trimester and parity matched normotensive pregnant women as controls. Levels of PT, aPTT, tPA, PAI-1, D-dimer protein were determined in blood samples of subjects and controls. Urinalysis was performed with dipstick method on their urine samples. Data generated was analysed using the IBM®SPSS 20.0 (2011) soft ware packages and the level of significance was a p-value <0.05. Results: The mean age of the respondents was 29.9±5.2 years. The median(25th-75th percentile) values of D-dimer, tPA, and PAI-1 of subjects were 730 (305.000-1560.000ng/ml), 0.11 (0.065-0,300ng/ml) and 3.65 (2.970-4,400ng/ml) respectively which were significantly higher than the corresponding values in the controls of 520 (24.000-1030.000ng/ml), 0.05 (0.040-0.090ng/ml and 2.650 (2.125-3.400ng/ml) respectively, p<0.05 each. Conclusion: The abnormal levels of PAI-1,D-dimer and tPA imply that they contribute to the exaggerated hypercoagulabilty state in pre-eclampsia thus, measuring their levels can help in the management of the condition.
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    PAI-1 and tPA as markers of severity among pre-eclamptics in a tertiary institution in north central Nigeria
    (2016) Oladosu-Olayiwola, Rashidat Oluwatosin; Olawumi, Hannah; Babatunde, Abiola S; Ijaiya, Munirdeen; Durotoye, Idayat; Biliaminu, Sikiru A; Ibraheem, Rasheedat M; Ogunfemi, Mutiat K
    Objectives: Endothelial dysfunction contributes to the pathogenesis of pre-eclampsia as well as increased production of some factors such as tissue plasminogen activator (tPA) and plasminogen activator inhibitor type-1 (PAI-1). These factors are said to be biomarkers of pre-eclampsia but their role in assessing the severity of pre-eclampsia is underreported. Methodology: A cross-sectional study involving 85 subjects with pre-eclampsia. They were classified clinically as having mild or severe pre-eclampsia using ACOG classification. Blood and urine samples were collected for determining tPA, PAI-1, D-dimer and proteinuria in the two groups. Clinical and laboratory values were compared using the IBM®SPSS 20.0 (2011) soft ware packages. Results: The mean age of the respondents was 29.9±5.2 years. Forty-five (52.9%) of the subjects had severe pre-eclampsia while 40(47.1%) had mild pre-eclampsia. The median values of tPA and PAI-1 of subjects with severe pre-eclampsia were significantly higher than the corresponding values in subjects with mild pre-eclampsia (each p=0.001). There was a positive correlation between each of the tPA and PAI-1 levels with the degree of severity of pre-eclampsia (p=0.001 each). Conclusion: Fibrinolytic proteins like tPA and PAI- 1 are useful in assessing the severity of preeclampsia.
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    Screening for Syphilis Among Blood Donors in Nigeria: Application of General Quality Principles
    (African Society for Blood Transfusion, 2019-12) Shittu, Akeem; Fadeyi, Abayomi; Olawumi, Hannah; Babatunde, Abiola; Omokanye Khadijat; Ogunfemi, Mutiat
    Background: Safety of blood for transfusion is a global concern. WHO and Africa Society for Blood Transfusion require a minimum of antibodies to Treponema pallidum or VDRL or RPR test on all donated blood units before transfusion. Application of general quality principle in screening for Transfusion Transmissible Infections, syphilis inclusive is a major determinant of safety of blood transfusion. Methods: Forty-eight health care facilities were recruited for the study between January and June 2018. A self-administered structured questionnaire, physical interactions and telephone calls were employed to collect all relevant data on quality measures, types of blood donors, total number of blood units screened and reactivity to syphilis screening tests. Results: Venereal Disease Research Laboratory method was used to screen all donations for syphilis at 81.3% of the facilities screened. Twenty seven of the 39 facilities that screened for syphilis validated their test kits, 24 facilities had written SOPs and quality control system while 33 and 6 facilities procured syphilis screening reagents through Hospital Managements and Departments. A total of 98 478 blood units were collected and screened for syphilis. Of the 831 samples found reactive, 405, 408 and 18 were obtained from tertiary, secondary and private hospitals and 384, 381 and 66 of the samples were from family replacement, paid and voluntary non-remunerated blood donors respectively. Conclusion: Majority of the facilities studied screened for syphilis using non-specific method and most employed general quality principles that conform to National and Africa Society for Blood Transfusion guidelines. Syphilis sero-prevalence of 0.84% was recorded in this study.