Browsing by Author "Olarenwaju, Olufunmilayo"

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    Toxicological, Biochemical and Histopathological Effects of Ethanol Extract of Clerodenrum volubile in rodents
    (Library and Publications Committee, University of Ilorin, Ilorin., 2020) Ologe, Mary Olufunmilayo; Olarenwaju, Olufunmilayo; Banjo, O. C; Alabi, Babatunde Adebola; Akinpelu, Bola O.; Akomolafe, Rufus O.; Iwalewa, Ezekiel Olugbenga
    Clerodendrum volubile is commonly known and consumed among other leafy vegetables in south-west and south-south Nigeria. This study was designed to evaluate the toxicological, biochemical and histopathological effects of Clerodendrum volubile ethanol extract in rodents. The toxicity profile of the ethanol extract of Clerodendrum volubile by determining its effects after acute and sub-chronic oral administration in mice and rats, respectively using standard methods. No death and signs of toxicity and no negative behavioral changes were observed in the extract at 5000 mg/kg in mice during the acute toxicity test. In rats, single oral alternate daily doses of Clerodendrum volubile extract (250, 500 and 1000 mg/kg), given for 30 days, resulted in increased body weights in treated rats compared to controls. No significant changes in organ weights were observed. There was no significant difference in the plasma activity of ALT and ALP in the treated rats compared with the control group. However, AST levels were significantly lower in the higher dose levels (500 and 1000 mg/kg) compared with the control group. The administration of the extract did not alter significantly AST and ALT activities in the liver. Kidney uric acid and creatinine concentrations revealed the extract had no deleterious effect on the kidney. No treatment-related histoarchitectural changes were observed in the liver and kidney. Clerodendrum volubile is safe for human consumption. However, it is advisable to apply some caution with its chronic use.