Browsing by Author "Oladosu, W. O."

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    Applicability of lipid ratios in the prediction of atherogenic risks of women on combined oral contraceptive pills in North-central Nigeria
    (Wolters-Kluwer (MedKnow), 2023-06-05) Jimoh, O. S.; Jimoh-Abdulghaffaar, Hidaayah Oluwamayowa; Bakare, T. Y.; Popoola, G. O.; Oladosu, W. O.; Grillo, E. O.; Ahmed, A.; Adeniran, A. S.
    Background: Combined Oral Contraceptive (COC) pill is associated with atherogenic and cardiovascular changes. Some service providers use individual lipid parameters to assess these changes unlike objective calculation using standard formulae. Objective: To determine and compare the atherogenic changes in women on COCs using six lipid ratios; coronary heart disease risk ratio, atherogenic index of plasma, atherogenic co-efficient, Cholesterol index, Castelli risk index I, and Castelli risk index II. Materials and Methods: A prospective, comparative study among new acceptors of contraceptives at four family planning clinics in Ilorin, North-Central Nigeria. Participants were categorized into COCs acceptors (group I, n=120) and acceptors of non-hormonal contraceptives (group II, n=120). Participants were followed up with serial lipid profiles at 0, 3 and 6 months after uptake. Atherogenic risks were calculated using six standard formulae; statistical analysis was with SPSS version 21.0 and Analysis of variance (ANOVA) was used to compare the differences of more than two means, Bonferroni Post Hoc test was used to test for specific significance within the group and p-value <0.05 was considered significant. Results: A total of 225 participants (111 COC users, 114 non-COC users) aged 19 to 48 years completed the study. Serum levels of Low-Density Lipoprotein showed a statistically significant rise among the COC users over the study period (p=0.038), especially between the third and sixth months. The lipid ratios were statistically increased using all six methods despite apparently normal lipid parameters. Conclusion: Atherogenic changes may occur in the presence of apparently normal lipid parameters among COC users; therefore, serial lipid ratio using standard method formulae is recommended.
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    Evaluating the effects of heavy metals on seminal fluid antioxidant status and semen parameters among males with infertility at a tertiary centre in Nigeria
    (Karnavati University, 2024-11-15) Oladosu, W. O.; Lawani, O. A.; Oyewo, R. A.; Oderinu, K. A.; Jimoh, O. S.; Motayo, B. O.; Jimoh-Abdulghaffaar, Hidaayah Oluwamayowa
    investigative tool of male infertility, has become necessary that focus should be on elucidating the aetiopathogenic causes of male fertility. This includes the impact of environmental toxic products such as levels of heavy metals that have been proposed to impact both the sperm quality and seminal antioxidant status. The study assessed how the seminal concentrations of specific heavy metals such as cadmium, lead and Iron affect the seminal fluid analysis (SFA) parameters and seminal antioxidant status of males exhibiting abnormal parameters of sperm, analysing infertile male patients consecutively in a cross‑sectional manner, with at least one abnormal SFA parameter, at a tertiary health centre. Materials and Methods: One hundred and thirty consenting males who have one or several anomalies with sperm characteristics were selected as subjects. Semen samples were collected, processed and centrifuged. The supernatants were analysed for the heavy metals using Buck Scientific 210/211VGP Flame Atomic Absorption Spectrophotometers 220GF Graphite Furnace and 220AS Autosampler and seminal Vitamins C and E, using spectrophotometric method and glutathione peroxidase, whereas catalase was analysed using ELISA method. Results: Subjects’ seminal levels of Cd, Fe and Pb were notably greater than those of controls, respectively. In addition, individuals’ levels of seminal antioxidants were noticeably lower than controls. Seminal antioxidant status and Seminal Cd, Fe and Pb were positive and negative significantly correlated with sperm count and active motility, respectively. Conclusion: Laboratory quantification of the seminal concentrations of these heavy metals in the evaluation of males with infertility, especially those still regarded as idiopathic, because of limitations of investigative tools and biomarkers, will be of clinical utility, in both the management and prevention of sperm quality deterioration