Browsing by Author "Oladele, Damilola"

Now showing 1 - 4 of 4
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    Clinical presentation of childhood tuberculosis in a Nigerian hospital: what are the implications?
    (The College of Health Sciences, University of Ilorin., 2017-04) Gobir, Aishatu; Ibraheem, Rasheedat; Johnson, Wahab; Muhammed, Sheni; Oladele, Damilola; Ojuola, O
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    Hepatotoxicity Due to Antituberculosis Therapy among Paediatric Patients Seen at the University of Ilorin Teaching Hospital, North Central Nigeria.
    (College of Health Sciences, Jimma University, Ethiopia, 2017-03) Gobir, Aishatu; Ibraheem, Rasheedat; Johnson, 'Wahab; Mohammed, Sheni; Oladele, Damilola; Ojuola, Adeniyi
    BACKGROUND: The liver is vulnerable to injury from the first line anti-tuberculosis drugs. This may result in mortality, long term morbidity and reduced compliance to therapy. Nigeria recently introduced fixed drug combinations in the treatment of children amid concerns of hepatotoxicity. A 6-year-old boy was treated in our unit had fulminant hepatic failure two weeks after completing his anti-tuberculosis therapy. This prompted the unit to investigate hepatotoxicity due to anti-tuberculosis therapy among children. There is no data on the incidence of hepatotoxicity due to antituberculosis therapy among Nigerian children, and no uniform guide to monitoring of patients exists. The objective of this study was to investigate the incidence of hepatotoxicity among children receiving anti-tuberculosis therapy. METHODS: A cross-sectional study was conducted among all 62 cases that completed treatment over a two year period. Liver Function Tests was done at baseline and 2 and 5 months of therapy. Elevation of Alanine aminotransferase and/or Aspartate aminotransferase above 3 times the reference values was considered an indication of hepatotoxicity. RESULTS: A total of 62 patients aged 3 months -17 years were treated at our unit during the study period. Twenty-two (35.5%) had elevated liver enzymes at baseline. Four (6.5%) had elevation of alanine aminotransferase of 3 times the upper limit at 2 months, but at 5 months, tests were within normal limits in all patients. Hepatotoxicity defined as liver enzymes above 3 times upper limit was not documented among the 62 cases treated over the period. CONCLUSION: Hepatotoxicity due to antituberculosis therapy is uncommon in children, hence repeated routine evaluation of liver function may not be necessary in all patients receiving anti-TB therapy.
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    Is this eosinophilic meningitis in a Nigerian child?.
    (The College of Health Sciences, University of Ilorin., 2016) Ibraheem, Rasheedat; Oladele, Damilola; Mohammed, S.S; Gobir, A.A
    Meningitis is a dreaded disease entity with a clinical course and prognosis that is dependent on its etiology, which is an important source of concern in ensuring proper management. The frequently implicated etiologic agents are bacterial and less often viral; however, rare causes requiring a different management approach may also masquerade as these common causes as is seen in eosinophilic meningitis (EoM). Against this background, the case of a Nigerian male child with suspected helminth‑induced EoM, management approach, and outcome is described.
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    Serum zinc levels as a predictor of clinical features and outcome of paediatric acute lower respiratory infections in Nigeria.
    (Peadiatric Association of Nigeria, 2013) Ibraheem, Rasheedat; Johnson, 'Wahab; Abdulkarim, Aishatu; Abdulkadir, Mohammed; Oladele, Damilola; Biliaminu, Sikiru
    Background: Malnutrition, especially macronutrient deficiency, has been shown to be interrelated with ALRI-related morbidity and mortality. However the import of zinc deficiency has only recently become the focus of research attention. Objective: The current study was carried out in Ilorin, Kwara State, Nigeria to determine the relationship between serum zinc levels, clinical features and outcome in hospitalized children with acute lower respiratory infections (ALRI). Method: A descriptive cross-sectional hospital-based study involving 120 children aged two months to five years with ALRI. Socio-demographic, clinical and laboratory data were obtained. The serum zinc was analyzed with a Jenway™ spectrophotometer after initial preparation with the QuantiChrom™ zinc assay kit. Results: Children with tachypnoea and crepitations had significantly lower mean serum zinc levels compared to the corresponding values in those without these features (each p<0.05). Significantly higher mean serum zinc level was recorded in children with grunting respiration compared with those without grunting (p=0.028). Age-related tachypnoea, grunting, and crepitations remained significant (each p<0.05) following a linear regression analysis. The mean serum zinc level in children with multiple complications was significantly lower than the corresponding level recorded in children who had one complication, p=0.020. No significant difference was found between the mean serum zinc level of the children who were discharged compared with the corresponding level recorded in those that died, p=0.589. Conclusion: The presence of crepitations had the strongest clinical association with a low serum zinc level. Children managed for ALRI would benefit from post-treatment zinc supplements and appropriate zinc-rich sources of food at discharge.