Browsing by Author "Ojulari Lekan Sheriff"

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    Anti-depressant Potentials of Some Bioactive Components of Basella alba Leaves in Chronic Unpredictable Stress Rat Model
    (Nigerian Journal of Neuroscience, 2023-04-20) Jimoh-Abdulghaffaar Hidaayah Oluwamayowa; Areola Emmanuel Damilare; Jimoh Olanrewaju Saheed; Sodimu Ayobami Tobi; Adebosin Victor Tope; Bakare Azeez Olawale; Ipinmoroti Deborah Ifeoluwa; Olagbemi Oluwafisolami; Yousuph Sarah Olanike; Egwa Jessica Okache; Ojulari Lekan Sheriff
    Bioactive components of Basella alba leaves are responsible for their antidepressant-like activity. However, the component with the greatest anti-depressant activity is unknown. This study investigated the antidepressant-like activities of the bioactive components (phenols, flavonoids, and glycosides) in Basella alba leaves. Forty-two male Wistar rats weighing 50–200 g were randomly divided into six groups (n=7). All the groups, except for the control, were subjected to chronic unpredictable stress (CUS) for five weeks. The rats in the CUS groups were treated with normal saline (1 mL/kg), escitalopram (5 mg/kg), and each of the phenol-, flavonoid-, and glycoside-rich Basella alba extracts (200 mg/kg) orally for twenty-one days. The tail suspension, sucrose preference, light-dark box, and hole-board tests were carried out before and after the induction of depression. In the CUS groups, reduced mobility time on tail suspension, increased percentage sucrose consumption, frequency of head dips on the hole board, and line-cross frequency in the light-dark box were observed. The latency on the hole board was reduced with Basella alba components, while there was a significant (p<0.05) decrease in serum brain-derived neurotrophic factor and an increase in serum IL-6 in the CUS animals not treated with extracts. The phenol-rich Basella alba extract showed the most potent antidepressantlike activity, followed by the flavonoid-rich extract. The bioactive components of Basella alba, particularly phenols, were effective in ameliorating the depressive features of CUS and should be further studied for use as an adjunct or standalone antidepressant.
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    Depressive State Assessment of Pregnant Women Attending the Antenatal Clinic of University of Ilorin Teaching Hospital (UITH), Ilorin, Kwara State, Nigeria
    (Anatomical Society of Nigeria, 2025-02-09) Jimoh-Abdulghaffaar Hidaayah Oluwamayowa; Gwadabe Sadiyah Musa; Jimoh Olanrewaju Saheed; Bello Sultan Adeola; Onwunali Maryprecious Nwakaego; Adeojo Ayomide Simidele; Gabriel Opeyemi Janet; Bamishe Gideon Adedotun; Alabi Miracle Tosin; Afolayan, Joshua Adeyinka; Abubakr Maimunat Kewukunmi; Okunnu Boluwatito Emmanuel; Isah Aaliyah Oiza; Lawal Abubakar Zubair; Lawal Rafiat Oluwatosin; Ayinla Maryam Tayo; Ojulari Lekan Sheriff
    Antenatal depression, with a global prevalence of between 15 and 65%, is a clinical condition characterised by persistent sadness, anxiety, and hopelessness during pregnancy. It is a strong predictor of postpartum depression, and it negatively impacts pregnancy outcomes, maternal-child bonding, and child development. Untreated antenatal depression could lead to an increased risk of obstetric complications, inadequate prenatal care, poor maternal nutrition, substance abuse, and in severe cases, maternal suicide. Despite being a significant global public health concern, antenatal depression is often overlooked in developing countries like Nigeria, both in terms of research and treatment. Consequently, only a few studies are focusing on antenatal depression, resulting in a poor understanding of the prevalence of depressive symptoms during pregnancy and their associated risk factors. This study aims to fill the gap in knowledge regarding antenatal depression in the Ilorin population. A cross-sectional study was conducted among over 200 pregnant women attending the antenatal clinic at the University of Ilorin Teaching Hospital, where participants were administered a battery of questionnaires (ANRQ, PHQ-9, and QIDSS-163) after obtaining informed consent. The results were analysed using. The results showed that the level of education (ANRQ, QIDSS-16), number of live births (QIDSS-16), age, and number of children (PHQ-9) have a positive impact on the risk and severity of antenatal depression in pregnant women attending the antenatal clinic at UITH. Age, level of education, number of live births, and number of children are strong predictors of the risk and severity of antenatal depression.
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    Favourable pregnancy outcome following gliclazide use throughout pregnancy in diabetic female Sprague-Dawley rats
    (Lagos State University College of Medicine, 2018) Ojulari Lekan Sheriff; Kadir Risikat Eniola; Abdulazeez Fatima I.; Ayinde Olarewaju Toafeek; Jimoh-Abdulghaffaar Hidaayah Oluwamayowa; Adegoke Olufeyisipe A.
    Objectives: The incidence of diabetes mellitus (DM) is associated with complications with reproduction. The effect of gliclazide on pregnancy hormones and fetal outcomes in diabetic female rats was determined in this study. Methods: There were four experimental groups (control, diabetic control, gliclazide-treated and diabetictreated) of 20 rats each. Studies were carried out on days 7, 14, 19 and at term, to ascertain implantation, gestation, fetal outcome and measurement of some plasma hormone levels. Values represent mean ± SD and were analyzed by two-tailed ANOVA followed by a Post-hoc test. Differences were considered significant at p<0.05. Results: There were increases inplasma estradiol in the gliclazide-treated non-diabetic [day 14 (55.80±1.0; p=0.01), day 19 (55.80±3.1;p=0.02)] and diabetic [day 14 (25.42±1.7); p=0.03] groups, and also in plasma progesterone in the treated diabetic group [day 14 (35.12±6.2) p=0.02] only. Plasma corticosterone and plasma CRP decreased in the gliclazide-treated [corticosterone day 14 (356.30±24.1) p=0.01; day 19 (308.30±17.6) p=0.01]; [CRP day 14 (0.13±0.05) p=0.01] and the diabetic-treated [corticosterone day 14 (400.50±21.5) p=0.01, day 19 (424.10±22.4) p=0.01; [CRP day 14 (0.14±0.13) p=0.01] groups. There were no significant changes in the plasma levels of β-hCG and no abnormalities were observed in litters from all groups. Conclusion: Gliclazide improved some reproductive complications in the diabetic state and in the nondiabetic state. Consideration should be given to its use in managing reproductive complications associated with DM.