Browsing by Author "Oguntoye, S. O."

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    Chemical constituents and antiproliferative properties of Turraea vogelli Hook. f. ex. Benth leaves.
    (University of Ilorin, 2015) Hamid, A. A.; Negi, A. S.; Zubair, M. F.; Oguntoye, S. O.; Aiyelaagbe, O. O
    Ethyl acetate and methanol extracts of Turraea vogelli leaves exhibited cytotoxic activity on leukaemia carcinoma K562 with IC50 values 85.00 and 85.22 μg/mL respectively. Isolation of the extracts afforded Tetradec-7-enoic acid (1), pentadec-1-ene (2), ethyl tridec-7-enoate (3), β-sitosterol (4) and stigmasterol (5). The structures of these compounds were characterised by IR, ID and 2D NMR and Mass spectroscopy, and supported with literature data. Compounds 1 and 4 exhibited antiproliferative activity against K562 tumor cell lines with IC50 of 57.27 and 27.56 μg/mL respectively. All isolated compounds exhibited low cytotoxicity against WRL and MCF-7 tumor cell lines.