Browsing by Author "Ogunfemi, M.K"
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Item Clinico-Laboratory Features of Multiple Myeloma in Selected Patients at University of Ilorin Teaching Hospital, North Central Nigeria(Library and Publications Committee, University of Ilorin, Nigeria, 2020-03) Babatunde, A.S; Omokanye, K.O; Ogunfemi, M.K; Owoeye, O.A; Sanni, E.O; Durotoye, I A.; Shittu, A.O.Multiple myeloma is an haematological disorder characterized by clonal proliferation of bone marrow plasma cells with production of increased amounts of monoclonal immunoglobulins which are detectable in blood and/or urine. The aim of the study was to describe the clinical and laboratory characteristics as well as treatment outcome in multiple myeloma patients diagnosed and managed at the Haematology Department of the University of Ilorin Teaching Hospital (U.I.T.H), Ilorin, North Central Nigeria, between 1 st January 2008 and 31 st December 2018. The study materials included bone marrow registers from the department and case folders of all multiple myeloma patients diagnosed within the study period. Relevant data including socio-demographic characteristics of patients, clinical features at presentation and laboratory tests results were extracted, documented and analyzed. Diagnosis was made in all patients based on the presence of major and/or minor criteria as described by the International Myeloma Working Group guidelines. Fifty eight (58) patients were diagnosed with multiple myeloma comprising of 31 males and 27 females (M:F ratio = 1.15:1). The median age of patients was 62.6 years (range = 39 – 85 years), and the most common presenting features included back pains (86.2%), bone pains (69%), inability to walk (67.2%) and anaemia (67.2%). High erythrocyte sedimentation rate > 30mm/Hr was seen in all patients (100%), Immunoglobulin G (Ig G) was the commonest monoclonal immunoglobulin demonstrated on serum protein electrophoresis (82.8%), and “punched out” osteolytic bone lesion on X-rays was demonstrated in 79.3% of cases. In resource- limited settings such as ours, the diagnosis and monitoring of patients with multiple myeloma still rely on the clinical and laboratory features of the disease to a large extent, hence the need for haemato-oncologists and physicians to be conversant with these features.Item Evaluation of the Indications and Diagnostic Value of Bone Marrow Examination in Haematological Disorders in Ilorin Nigeria: A Review of 496 Cases(College of Health Sciences, University of Ilorin, 2020) Babatunde, A.S.; Durotoye, I.A.; Shittu, A.O.; Omokanye, K.O.; Ogunfemi, M.K; Owoeye, O.A.Abstract: Bone marrow examination, either in the form of aspiration or biopsy, is an invasive procedure which is relatively safe and is still being performed routinely in the investigation and diagnosis of various malignant and non-malignant haematological disorders. The aims of this study were to evaluate the role of bone marrow examination in the investigation and diagnosis of haematological disorders, and the pattern of disorders diagnosed by bone marrow examination in our centre. This study was a retrospective review of all cases of bone marrow examinations which were carried out at the Haematology department of U.I.T.H Ilorin between 1st January 2005 and 31st December 2018. Case folders of all patients who had bone marrow examination done during the study period, Bone marrow aspiration and biopsy registers from Haematology department, Bone marrow reports and Full blood counts (FBC) results were retrieved and analyzed. Relevant clinical information retrieved included age, gender, clinical features at presentation, laboratory investigations, treatment regimen, and survival outcome among others. A total of 496 cases had BME performed during the study period. The patients comprised 276 (55.8%) males and 220 (44.2%) females with a M:F ratio of 1.3:1. Their median age was 38.5 years (age range 16 months and 85 years). Pathological marrow with diagnosis on BME was found in 441 (88.9%) while normal marrow (negative for any pathologic condition) was seen in 55 (11.1%) of patients. The leukemias (acute and chronic) were the commonest haematological disorders found on bone marrow examination, constituting 37.8% of cases. Unexplained anaemia was the commonest clinical feature at presentation necessitating bone marrow examination. Bone marrow examination is still very useful as a diagnostic tool in the hand of Haematologists in the investigation and diagnosis of various haematological disorders, and is relatively safe to perform even with presence of thrombocytopenia.Item Prevalence of antibody to hepatitis B core antigen among hepatitis B surface antigen-negative blood donors in Ilorin, Nigeria(Malawi Medical Association, Malawi, 2017-03) Ogunfemi, M.K; Olawumi, H.O.; Olokoba, A.B; Kagu, M.B; Biliaminu, K.A; Durowade, K.A; Durotoye, I A.; Shittu, A.O.Background Post-transfusion hepatitis occurs even with stringent donor selection criteria and screening for hepatitis B surface antigen (HBsAg). The objective of this study was to determine the prevalence of antibody to hepatitis B core antigen (anti-HBc) in HBsAg-negative blood donors. Methods This was a cross-sectional study in which 200 HBsAg-negative blood donors were recruited. Screening for viral markers was done using both a rapid test kit and enzyme-linked immunosorbent assay (ELISA) for anti-HBc IgM. Quantitative and qualitative analysis of anti-HBc IgM was done by “capture” enzyme immunoassay using DIA.PRO HBc IgM test kit. The other viral markers were investigated using one step cassette style HBV tests. SPSS (version 16) was used for data analysis. A P-value of 0.05 or less was considered significant. Results There were 190 male (95%) and 10 female (5%) blood donors, with a mean age of 31.7 ± 7.9 years. The prevalence of anti-HBc IgM was 4%. The other viral markers (HBeAg, anti-HBeAg, anti-HBs and total anti-HBc) had a prevalence of 1.5%, 23%, 2.5%, and 32.5%, respectively. Conclusions The prevalence of anti-HBc IgM in this study wsa high, and this supports the fact that screening blood donors for HBsAg alone is not sufficient to prevent transmission of HBV.